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- Title
Anastrozole-related acute hepatitis with autoimmune features: a case report.
- Authors
Inno, Alessandro; Basso, Michele; Vecchio, Fabio M.; Marsico, Valentina A.; Cerchiaro, Eleonora; D'Argento, Ettore; Bagalà, Cinzia; Barone, Carlo
- Abstract
Background: Two cases of acute hepatitis occurring during treatment with anastrozole have previously been reported, but the underlying mechanisms of liver injury are still uncertain. We report the case of anastrozole-related acute hepatitis with some autoimmune features. Case presentation: A 70-year-old woman developed acute hepatitis associated with serum antinuclear antibodies during anastrozole treatment; after drug withdrawal, liver function parameters rapidly improved and serum auto-antibodies were no longer detectable. Conclusions: Anastrozole-induced hepatotoxicity is a very rare event. Drug-drug interactions or metabolically-mediated damage might be involved, with a possible role of individual susceptibility. Our report suggests that an immune-mediated mechanism may also be considered in anastrozole-related liver injury. Keywords: Anastrozole drug-induced liver injury, autoimmune hepatitis, hepatotoxicity, antinuclear antibodies, case report
- Subjects
HEPATITIS; IMMUNOGLOBULINS; HEPATOTOXICOLOGY; QUALITATIVE research
- Publication
BMC Gastroenterology, 2011, Vol 11, Issue 1, p32
- ISSN
1471-230X
- Publication type
Case Study
- DOI
10.1186/1471-230X-11-32