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- Title
Diabetes and Depression in Pregnancy: Is There an Association?
- Authors
Katon, Jodie G.; Russo, Joan; Gavin, Amelia R.; Melville, Jennifer L.; Katon, Wayne J.
- Abstract
Background: Prior studies have reported inconsistent findings regarding the association of antenatal depression with pregnancy-related diabetes. This study examined the association of diabetes and antenatal depression. Methods: We conducted a cross-sectional analysis of baseline data from a prospective cohort study of pregnant women receiving prenatal care at a single University of Washington Medical Center clinic between January 2004 and January 2009. The primary exposure was diabetes in pregnancy (no diabetes, preexisting diabetes, or gestational diabetes [GDM]). Antenatal depression was defined by the Patient Health Questionnaire-9 (PHQ-9) score or current use of antidepressants. Antenatal depression was coded as (1) any depression (probable major or minor depression by PHQ-9 or current antidepressant use) and (2) major depression (probable major depression by PHQ-9 or current antidepressant use). Logistic regression was used to quantify the association between diabetes in pregnancy and antenatal depression. Results: The prevalences of preexisting diabetes, GDM, any antenatal depression, and major antenatal depression were 9%, 18%, 13.6%, and 9.8%, respectively. In the unadjusted analysis, women with preexisting diabetes had 54% higher odds of any antenatal depression compared to those without diabetes (odds ratio [OR] 1.54, 95% confidence interval [CI] 1.08-2.21). After adjusting for important covariates the association was attenuated (OR 1.16, 95% CI 0.79-1.71). Results were similar for antenatal major depression. GDM was not associated with increased odds for any antenatal depression or antenatal major depression. Conclusions: Neither preexisting diabetes nor GDM was independently associated with increased risk of antenatal depression.
- Subjects
WASHINGTON (State); ANTIDEPRESSANTS; ANALYSIS of variance; CONFIDENCE intervals; STATISTICAL correlation; MENTAL depression; GESTATIONAL diabetes; EPIDEMIOLOGY; ELECTRONIC health records; PRENATAL care; LOGISTIC regression analysis; DATA analysis; DISEASE prevalence; CROSS-sectional method
- Publication
Journal of Women's Health (15409996), 2011, Vol 20, Issue 7, p983
- ISSN
1540-9996
- Publication type
Journal Article
- DOI
10.1089/jwh.2010.2662