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- Title
A novel antibiotic produced by streptomyces noursei Da07210.
- Authors
Xiaopeng Wu; Huiqin Huang; Guangying Chen; Qianguang Sun; Jie Peng; Jun Zhu; Shixiang Bao
- Abstract
Abstract A novel antibiotic 210-A, named as (6S,8aS,9S,11S,12aR)-6-hydroxy-9,10-dimethyldecahydrobenzo[d]azecine-2,4,12(3H)-trione, was isolated from the fermentation broth of Streptomyces noursei Da07210, its structure was unambiguously established by spectral analyses and chemical comparison with related cycloheximide. Experiments demonstrated that 210-A bore strong activity against Fusarium oxysporum f. sp. cubense race four (Foc race four), which also showed antitumor activity against SMMC-7721 human hepatocarcinoma cells and S180 murine sarcoma, and the IC50 values were 0.77 and 0.74 μg/ml, respectively.
- Subjects
STREPTOMYCES; STREPTOMYCETACEAE; STREPTOMYCES actuosus; STREPTOMYCES aureofaciens
- Publication
Antonie van Leeuwenhoek, 2009, Vol 96, Issue 1, p109
- ISSN
0003-6072
- Publication type
Article
- DOI
10.1007/s10482-009-9333-8