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- Title
[<sup>99m</sup>Tc]Tc-Phosphate-buffer system as a potential tracer for bone imaging.
- Authors
Pereira, Nara Caroline; de Oliveira Silva, Juliana; De Sousa, Frederico B.; Miranda, Sued Eustáquio Mendes; Soares, Daniel Crístian Ferreira; de Barros, André Luis Branco
- Abstract
In this study, phosphate-buffered saline solution (PBS) was successfully radiolabeled with technetium-99m. The biodistribution profile and bone accumulation of the [99mTc]Tc-PBS system were evaluated in healthy swiss mice. The radiolabeling of the system was successfully obtained, yielding around 90 % of radiochemical purity. The system stability was tested in the presence of saline medium at 25 ºC and mouse plasma at 37 ºC, and results revealed that [99mTc]Tc-PBS showed excellent stability over time, in both media. It was observed a biphasic clearance profile, with fast elimination from the bloodstream by renal filtration. The radiolabeled system revealed a high specificity bone accumulation was observed, demonstrating an uptake behavior from 20 to 50 times higher than muscle, used as control. From all results obtained, the system constituted by [99mTc]Tc-PBS can be considered a potential selective agent for bone imaging.
- Subjects
RADIOCHEMICAL purification; LABORATORY mice; SALINE solutions; RADIOLABELING
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2021, Vol 329, Issue 2, p1119
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-021-07869-8