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- Title
Bioactive glass induced in vitro apatite formation on composite GBR membranes.
- Authors
Tirri, Teemu; Rich, Jaana; Wolke, Joop; Seppälä, Jukka; Yli-Urpo, Antti; Närhi, Timo O.
- Abstract
The aim of this study was to investigate in vitro bioactivity of different thermoplastic biodegradable barrier membranes. Three experimental GBR membranes were fabricated using Poly(ε-caprolactone-co- d, l-lactide) P(CL/DL-LA) and particulate bioactive glass S53P4 (BAG; granule size 90–315 μm): (A) composite membrane with 60-wt.% of BAG, (B) membrane coated with BAG; and (C) copolymer membrane without BAG. Membranes were immersed in simulated body fluid (SBF), and their surfaces were characterized with SEM, XRD and EDS after 6 and 12 h and after 1, 3, 5, 7, and 14 days. Calcium phosphate (Ca-P) surface formation was observed on both composite membranes (A and B) but not on the copolymer membrane without bioactive glass (C). The Ca-P precipitation appeared to be initiated on the bioactive glass followed by growth of the layer along the polymer surface. In 6–12 h ion dissolution of the bioactive glass led to formation of the silica rich layer on the surface of the exposed glass granules on composite membrane B whereas only small amounts of silica was observed on the polymer surface of the composite membrane A. At 24 h nucleation of Ca-P precipitation was observed, and by 3–5 days membrane surface was covered with a uniform Ca-P layer transforming from amorphous to low crystalline structure. At 7 days composition and structure of the apatite surface resembled the apatite in bone. Once nucleated, the surface topography seemed to have significant effect on the growth of the apatite layer.
- Subjects
BIODEGRADABLE products; BIOACTIVE compounds; THERMOPLASTICS; BODY fluids; POLYMERS; NUCLEATION; APATITE; SILICON compounds; CALCIUM phosphate
- Publication
Journal of Materials Science: Materials in Medicine, 2008, Vol 19, Issue 8, p2919
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-007-3308-y