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- Title
Population data and genetic characteristics of 12 X-STR loci using the Investigator® Argus X-12 Quality Sensor kit for the Kedayan population of Borneo in Malaysia.
- Authors
Hakim, Hashom Mohd; Khan, Hussein Omar; Ismail, Siti Afifah; Lalung, Japareng; Kofi, Abban Edward; Aziz, Mohd Yusmaidie; Pati, Siddhartha; Nelson, Bryan Raveen; Chambers, Geoffrey Keith; Edinur, Hisham Atan
- Abstract
DNA profiling of X-chromosomal short tandem repeats (X-STR) has exceptional value in criminal investigations, especially for complex kinship and incest cases. In this study, Investigator® Argus X-12 Quality Sensor (QS) kits were successfully used to characterize 12 X-STR loci in 199 unrelated healthy Kedayan individuals living in Sabah and Sarawak, Malaysia. The LG1 haplogroup (DXS8378 – DXS10135 – DXS10148) has the largest HD (0.9799) as compared with all other closely linked haplotype groups examined (LG2; DXS7132-DXS10074-DXS10079, LG3; DXS10103-DXS10101-HPRTB and LG4; DXS10134-DXS7423-DXS10146). Data from statistical analysis showed that high combined of PDM, PDF, MEC_Krüger, MEC_Kishida, MEC_Desmarais, and MEC_Desmarais_duo values (0.999999994405922, 0.99999999999999, 0.999990463834938, 0.999999975914808, 0.999999975985006, and 0.999996491927194, respectively) in the Kedayan. In a two-dimensional scaling (MDS) plot and dendrogram constructed using allele frequencies at the 12 X-STR loci, Kedayan appear to be most closely related to their other Austronesian populations including the Malays and Filipinos as compared with other reference population groups. Findings from the present study thus demonstrate high genetic variability across the 12 tested X-STR loci and can be used for population studies and forensic applications.
- Subjects
MALAYSIA; BORNEO; SABAH; MICROSATELLITE repeats; FORENSIC genetics; CRIMINAL investigation; DETECTORS; GENE frequency; DNA fingerprinting; KINSHIP
- Publication
International Journal of Legal Medicine, 2021, Vol 135, Issue 4, p1433
- ISSN
0937-9827
- Publication type
Article
- DOI
10.1007/s00414-021-02577-0