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- Title
Synthesis of trans-6-(4-chlorobenzoyl)-7-(aryl)-1,3-dimethyl-6,7-dihydrofuro[3,2-d]pyrimidine-2,4-diones using choline hydroxide as an efficient catalyst in an aqueous medium.
- Authors
Salari, Maryam; Hassanabadi, Alireza; Mosslemin, Mohammad H.
- Abstract
A green and efficient synthesis of the trans-6-(4-chlorobenzoyl)-7-(aryl)-1,3-dimethyl-6,7-dihydrofuro[3,2-d]pyrimidine-2,4-diones has been achieved via a three-component, one-pot condensation of 2-[2-(4-chlorophenyl)-2-oxoethyl)]isoquinolinium bromide with 1,3-dimethylbarbituric acid and an aromatic aldehyde in the presence of catalytic amounts of choline hydroxide in water under reflux conditions. This gives trans-6-(4-chlorobenzoyl)-7-(aryl)-1,3-dimethyl-6,7-dihydrofuro[3,2-d]pyrimidine-2,4-diones in excellent yield and in short reaction times.
- Subjects
ETHANE derivatives; CHLOROBENZOATES; PYRIMIDINE synthesis; CONDENSATION; CHOLINE kinase
- Publication
Journal of Chemical Research, 2017, Vol 41, Issue 3, p139
- ISSN
1747-5198
- Publication type
Article
- DOI
10.3184/174751917X14859570937794