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- Title
Synthesis and Anticonvulsant Activity of N-Substituted 4-Amino-3-Nitrocoumarins.
- Authors
Mokrov, G. V.; Savel'ev, V. L.; Voronina, T. A.; Litvinova, S. A.; Kovalev, I. G.; Nerobkova, L. N.; Dmitrienko, A. O.; Gudasheva, T. A.; Seredenin, S. B.
- Abstract
The synthesis and anticonvulsant activity of new coumarin derivatives are reported. N-(3-Nitrocoumarin-4-yl)-4-aminobutyric acid (1a) at doses of 60 and 80 mg/kg (in the MES test) and methyl N-(3,6-dinitrocoumarin-4-yl)-4-aminobutyrate (1e) at doses of 20 and 40 mg/kg (in the corazole antagonism test) possessed the greatest anticonvulsant activity of the synthesized compounds. The results indicated that the coumarin derivatives were promising for further development as potential anticonvulsant agents.
- Subjects
CHEMICAL synthesis; ANTICONVULSANTS; COUMARINS; ELECTRIC shock; COUMARIN derivatives; INTERFERON beta-1a; ELECTRIC testing
- Publication
Pharmaceutical Chemistry Journal, 2019, Vol 53, Issue 2, p118
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-019-01964-7