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- Title
Bacteriostatic activity and decomposition products of rifampicin in aqueous solution and liposomal composition.
- Authors
Sorokoumova, G. M.; Vostrikov, V. V.; Selishcheva, A. A.; Rogozhkina, E. A.; Kalashnikova, T. Yu.; Shvets, V. I.; Golyshevskaya, V. I.; Martynova, L. P.; Erokhin, V. V.
- Abstract
Products of the decomposition and oxidation of rifampicin were obtained; characterized by spectrophotometry, TLC, and HPLC; and identified by mass spectrometry. The stability of the drug in aqueous solutions and in liposomal compositions at 4 and 25°C was evaluated. The main product of rifampicin decomposition on storage is 3-formylrifampicin SV. The antimicrobial activity of the antibiotic in liposomal compositions is the same as that in aqueous solutions and is well retained on storage.
- Subjects
OXIDATION; CHEMICAL decomposition; SPECTROPHOTOMETRY; ANTI-infective agents; LIPOSOMES
- Publication
Pharmaceutical Chemistry Journal, 2008, Vol 42, Issue 8, p475
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-008-0153-3