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- Title
EPIGENETICS OF ALLERGIC RHINITIS: POTENTIAL FOR THERAPEUTIC APPLICATIONS.
- Authors
Jana, Halušková
- Abstract
The incidence of allergic rhinitis (AR) is increasing worldwide. AR is defined as an IgE antibodymediated inflammatory disease and is closely related to other inflammatory disorders such as asthma or conjunctivitis. External environmental factors such as exposition to allergens, air pollution, climate change, ozone, or the presence of toxicants in combination with genetic factors play a role in the induction of AR. More recently, epigenetic mechanisms have also been found to be involved in the pathogenesis of AR, thought to mediate the link between genetic and environmental factors. In the present work, studies analysing basic epigenetic mechanisms in AR, such as DNA methylation, histone modification, and miRNA expression are presented. The potential of epigenetics for the therapy of AR is also included.
- Subjects
ALLERGIC rhinitis; RHINITIS treatment; MICRORNA; IMMUNOGLOBULIN E; AIR pollution
- Publication
Folia Pharmaceutica Cassoviensia, 2023, Vol 5, Issue 2, p14
- ISSN
2585-9609
- Publication type
Article