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- Title
A parsimonious threshold-independent protein feature selection method through the area under receiver operating characteristic curve.
- Authors
Zhanfeng Wang; Chang, Yuan-chin I.; Zhiliang Ying; Liang Zhu; Yaning Yang
- Abstract
Motivation: Protein expression profiling for differences indicative of early cancer holds promise for improving diagnostics. Due to their high dimensionality, statistical analysis of proteomic data from mass spectrometers is challenging in many aspects such as dimension reduction, feature subset selection as well as construction of classification rules. Search of an optimal feature subset, commonly known as the feature subset selection (FSS) problem, is an important step towards disease classification/diagnostics with biomarkers.
- Subjects
PROTEINS; GENE expression; CANCER diagnosis; CANCER genetics; BIOMARKERS; TUMOR markers
- Publication
Bioinformatics, 2007, Vol 23, Issue 20, p2788
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btm442