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Repotrectinib: Redefining the therapeutic landscape for patients with ROS1 fusion‐driven non‐small cell lung cancer.
Published in:
Clinical & Translational Medicine, 2024, v. 14, n. 10, p. 1, doi. 10.1002/ctm2.70017
By:
- Desilets, Antoine;
- Repetto, Matteo;
- Drilon, Alexander
Publication type:
Article
Case report: dynamic personalized physiological monitoring in lung cancer using wearable data.
Published in:
Frontiers in Oncology, 2024, p. 1, doi. 10.3389/fonc.2024.1420888
By:
- Bliss, Joshua W.;
- Underwood, Whitney P.;
- Carlson, Adele M.;
- Scott, Jessica M.;
- Daly, Robert;
- Li, Bob T.;
- Drilon, Alexander;
- Stetson, Peter;
- Boutros, Paul C.;
- Jones, Lee W.
Publication type:
Article
RET Inhibitors in RET Fusion-Positive Lung Cancers: Past, Present, and Future.
Published in:
Drugs, 2024, v. 84, n. 9, p. 1035, doi. 10.1007/s40265-024-02040-5
By:
- Chen, Monica F.;
- Repetto, Matteo;
- Wilhelm, Clare;
- Drilon, Alexander
Publication type:
Article
NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors.
Published in:
Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-01508-w
By:
- Somwar, Romel;
- Hofmann, Nicolle E.;
- Smith, Bryan;
- Odintsov, Igor;
- Vojnic, Morana;
- Linkov, Irina;
- Tam, Ashley;
- Khodos, Inna;
- Mattar, Marissa S.;
- de Stanchina, Elisa;
- Flynn, Daniel;
- Ladanyi, Marc;
- Drilon, Alexander;
- Shinde, Ujwal;
- Davare, Monika A.
Publication type:
Article
Mitogen-Activated Pathway Kinase Inhibitor-Associated Retinopathy: Do Features Differ with Upstream versus Downstream Inhibition?
Published in:
Ocular Oncology & Pathology, 2023, v. 9, n. 1/2, p. 25, doi. 10.1159/000529127
By:
- Francis, Jasmine H.;
- Foulsham, William;
- Canestraro, Julia;
- Harding, James J.;
- Diamond, Eli L.;
- Abramson, David H.;
- Drilon, Alexander
Publication type:
Article
Case Report: Complete pathologic response to neoadjuvant selpercatinib in a patient with resectable early-stage RET fusion-positive non-small cell lung cancer.
Published in:
Frontiers in Oncology, 2023, p. 1, doi. 10.3389/fonc.2023.1178313
By:
- Goldman, Jonathan W.;
- Sholl, Lynette M.;
- Dacic, Sanja;
- Fishbein, Michael C.;
- Murciano-Goroff, Yonina R.;
- Rajaram, Ravi;
- Szymczak, Sylwia;
- Szpurka, Anna M.;
- Chao, Bo H.;
- Drilon, Alexander
Publication type:
Article
RET -Altered Cancers—A Tumor-Agnostic Review of Biology, Diagnosis and Targeted Therapy Activity.
Published in:
Cancers, 2023, v. 15, n. 16, p. 4146, doi. 10.3390/cancers15164146
By:
- Desilets, Antoine;
- Repetto, Matteo;
- Yang, Soo-Ryum;
- Sherman, Eric J.;
- Drilon, Alexander
Publication type:
Article
Larotrectinib versus Prior Therapies in Tropomyosin Receptor Kinase Fusion Cancer: An Intra-Patient Comparative Analysis.
Published in:
Cancers, 2020, v. 12, n. 11, p. 3246, doi. 10.3390/cancers12113246
By:
- Italiano, Antoine;
- Nanda, Shivani;
- Briggs, Andrew;
- Garcia-Foncillas, Jesus;
- Lassen, Ulrik;
- Vassal, Gilles;
- Kummar, Shivaani;
- van Tilburg, Cornelis M.;
- Hong, David S.;
- Laetsch, Theodore W.;
- Keating, Karen;
- Reeves, John A.;
- Fellous, Marc;
- Childs, Barrett H.;
- Drilon, Alexander;
- Hyman, David M.
Publication type:
Article
Targeting NTRK Fusions Across Tumor Types.
Published in:
Oncology (08909091), 2021, v. 35, n. 8, p. 504
By:
- Drilon, Alexander
Publication type:
Article
Larotrectinib Treatment for Patients With TRK Fusion-Positive Salivary Gland Cancers.
Published in:
Oncologist, 2024, v. 29, n. 6, p. e779, doi. 10.1093/oncolo/oyac080
By:
- Le, Xiuning;
- Baik, Christina;
- Bauman, Jessica;
- Gilbert, Jill;
- Brose, Marcia S;
- Grilley-Olson, Juneko E;
- Patil, Tejas;
- McDermott, Ray;
- Raez, Luis E;
- Johnson, Jennifer M;
- Shen, Lin;
- Tahara, Makoto;
- Ho, Alan L;
- Norenberg, Ricarda;
- Dima, Laura;
- Brega, Nicoletta;
- Drilon, Alexander;
- Hong, David S
Publication type:
Article
A Phase I, First‐in‐Human Study of GSK2849330, an Anti‐HER3 Monoclonal Antibody, in HER3‐Expressing Solid Tumors.
Published in:
Oncologist, 2021, v. 26, n. 10, p. e1844, doi. 10.1002/onco.13860
By:
- Gan, Hui K.;
- Millward, Michael;
- Jalving, Mathilde;
- Garrido‐Laguna, Ignacio;
- Lickliter, Jason D.;
- Schellens, Jan H.M.;
- Lolkema, Martijn P.;
- Van Herpen, Carla L.M.;
- Hug, Bruce;
- Tang, Lihua;
- O'Connor‐Semmes, Robin;
- Gagnon, Robert;
- Ellis, Catherine;
- Ganji, Gopinath;
- Matheny, Christopher;
- Drilon, Alexander
Publication type:
Article
Therapeutic Potential of Afatinib in NRG1 Fusion‐Driven Solid Tumors: A Case Series.
Published in:
Oncologist, 2021, v. 26, n. 1, p. 7, doi. 10.1634/theoncologist.2020-0379
By:
- Cadranel, Jacques;
- Liu, Stephen V.;
- Duruisseaux, Michaël;
- Branden, Eva;
- Goto, Yasushi;
- Weinberg, Benjamin A.;
- Heining, Christoph;
- Schlenk, Richard F.;
- Cheema, Parneet;
- Jones, Martin R.;
- Drilon, Alexander;
- Trombetta, Domenico;
- Muscarella, Lucia Anna;
- Tolba, Khaled;
- Gounant, Valerie;
- Cseh, Agnieszka;
- Solca, Flavio;
- Laskin, Janessa J.;
- Renouf, Daniel J.
Publication type:
Article
Acute Promyelocytic Leukemia in HIV-Infected Adults: A Case Report and Review of Therapeutic Considerations.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2010, v. 10, n. 5, p. E47, doi. 10.3816/CLML.2010.n.075
By:
- Drilon, Alexander D.;
- Gamboa, Eric O.;
- Koolaee, Roodabeh;
- Goel, Anupama
Publication type:
Article
Frequency and outcomes of brain metastases in patients with HER2-mutant lung cancers.
Published in:
2019
By:
- Offin, Michael;
- Feldman, Daniel;
- Ni, Ai;
- Myers, Mackenzie L.;
- Lai, W. Victoria;
- Pentsova, Elena;
- Boire, Adrienne;
- Daras, Mariza;
- Jordan, Emmet J.;
- Solit, David B.;
- Arcila, Maria E.;
- Jones, David R.;
- Isbell, James M.;
- Beal, Kathryn;
- Young, Robert J.;
- Rudin, Charles M.;
- Riely, Gregory J.;
- Drilon, Alexander;
- Tabar, Viviane;
- DeAngelis, Lisa M.
Publication type:
journal article
Beyond the dose-limiting toxicity period: Dermatologic adverse events of patients on phase 1 trials of the Cancer Therapeutics Evaluation Program.
Published in:
2016
By:
- Drilon, Alexander;
- Eaton, Anne A.;
- Schindler, Katja;
- Gounder, Mrinal M.;
- Spriggs, David R.;
- Harris, Pamela;
- Ivy, S. Percy;
- Iasonos, Alexia;
- Lacouture, Mario E.;
- Hyman, David M.
Publication type:
journal article
Author Correction: TKI type switching overcomes ROS1 L2086F in ROS1 fusion-positive cancers.
Published in:
2024
By:
- Thawani, Rajat;
- Repetto, Matteo;
- Keddy, Clare;
- Nicholson, Katelyn;
- Jones, Kristen;
- Nusser, Kevin;
- Beach, Catherine Z.;
- Harada, Guilherme;
- Drilon, Alexander;
- Davare, Monika A.
Publication type:
Correction Notice
TKI type switching overcomes ROS1 L2086F in ROS1 fusion-positive cancers.
Published in:
NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00663-1
By:
- Thawani, Rajat;
- Repetto, Matteo;
- Keddy, Clare;
- Nicholson, Katelyn;
- Jones, Kristen;
- Nusser, Kevin;
- Beach, Catherine Z.;
- Harada, Guilherme;
- Drilon, Alexander;
- Davare, Monika A.
Publication type:
Article
Complete Pathological Response to Crizotinib in a Patient with ALK-rearranged Lung Adenocarcinoma.
Published in:
2020
By:
- Mattar, Marissa S.;
- Chang, Jason;
- Benayed, Ryma;
- Halpenny, Darragh;
- Powers, Astin;
- Kleiner, David E.;
- Drilon, Alexander;
- Kris, Mark G.
Publication type:
journal article
Extended-Duration Therapy in Advanced Non-Small-Cell Lung Cancer: Promise and Pitfalls.
Published in:
Clinical Lung Cancer, 2010, v. 11, n. 6, p. 383, doi. 10.3816/CLC.2010.n.050
By:
- Levy, Benjamin;
- Drilon, Alexander;
- Siu, KarLeung;
- Grossbard, Michael
Publication type:
Article
Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34109-8
By:
- Murciano-Goroff, Yonina R.;
- Schram, Alison M.;
- Rosen, Ezra Y.;
- Won, Helen;
- Gong, Yixiao;
- Noronha, Anne Marie;
- Janjigian, Yelena Y.;
- Stadler, Zsofia K.;
- Chang, Jason C.;
- Yang, Soo-Ryum;
- Mandelker, Diana;
- Offit, Kenneth;
- Berger, Michael F.;
- Donoghue, Mark T. A.;
- Bandlamudi, Chaitanya;
- Drilon, Alexander
Publication type:
Article
Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30496-0
By:
- Gounder, Mrinal M.;
- Agaram, Narasimhan P.;
- Trabucco, Sally E.;
- Robinson, Victoria;
- Ferraro, Richard A.;
- Millis, Sherri Z.;
- Krishnan, Anita;
- Lee, Jessica;
- Attia, Steven;
- Abida, Wassim;
- Drilon, Alexander;
- Chi, Ping;
- Angelo, Sandra P. D';
- Dickson, Mark A.;
- Keohan, Mary Lou;
- Kelly, Ciara M.;
- Agulnik, Mark;
- Chawla, Sant P.;
- Choy, Edwin;
- Chugh, Rashmi
Publication type:
Article
Systemic Approaches for Multifocal Bronchioloalve-olar Carcinoma: Is There an Appropriate Target?
Published in:
Oncology (08909091), 2010, v. 24, n. 10, p. 888
By:
- Levy, Benjamin P.;
- Drilon, Alexander;
- Makarian, Liana;
- Patel, Amit A.;
- Grossbard, Michael L.
Publication type:
Article
NTRK1 Fusions identified by non-invasive plasma next-generation sequencing (NGS) across 9 cancer types.
Published in:
British Journal of Cancer, 2022, v. 126, n. 3, p. 514, doi. 10.1038/s41416-021-01536-1
By:
- Rolfo, Christian;
- Drilon, Alexander;
- Hong, David;
- McCoach, Caroline;
- Dowlati, Afshin;
- Lin, Jessica J.;
- Russo, Alessandro;
- Schram, Alison M.;
- Liu, Stephen V.;
- Nieva, Jorge J.;
- Nguyen, Timmy;
- Eshaghian, Shahrooz;
- Morse, Michael;
- Gettinger, Scott;
- Mobayed, Mohammad;
- Goldberg, Sarah;
- Araujo-Mino, Emilio;
- Vidula, Neelima;
- Bardia, Aditya;
- Subramanian, Janakiraman
Publication type:
Article
NTRK1 Fusions identified by non-invasive plasma next-generation sequencing (NGS) across 9 cancer types.
Published in:
2022
By:
- Rolfo, Christian;
- Drilon, Alexander;
- Hong, David;
- McCoach, Caroline;
- Dowlati, Afshin;
- Lin, Jessica J;
- Russo, Alessandro;
- Schram, Alison M;
- Liu, Stephen V;
- Nieva, Jorge J;
- Nguyen, Timmy;
- Eshaghian, Shahrooz;
- Morse, Michael;
- Gettinger, Scott;
- Mobayed, Mohammad;
- Goldberg, Sarah;
- Araujo-Mino, Emilio;
- Vidula, Neelima;
- Bardia, Aditya;
- Subramanian, Janakiraman
Publication type:
journal article
Efficacy and Safety of NTRK Inhibitors in Patients With NTRK Fusion-Positive Lung and Thyroid Cancers.
Published in:
Clinical Advances in Hematology & Oncology, 2024, v. 22, p. 1
By:
- Hong, David S.;
- Drilon, Alexander;
- Wirth, Lori J.
Publication type:
Article
Management of Patients with NTRK Fusion-Positive Lung Cancer.
Published in:
Clinical Advances in Hematology & Oncology, 2024, v. 22, p. 5
By:
- Drilon, Alexander
Publication type:
Article
Q&A: Barriers to Testing for NTRK Fusions in Metastatic Lung and Thyroid Cancer.
Published in:
Clinical Advances in Hematology & Oncology, 2024, v. 22, p. 16
By:
- Hong, David S.;
- Drilon, Alexander;
- Wirth, Lori J.
Publication type:
Article
The METeoric rise of MET in lung cancer.
Published in:
Cancer (0008543X), 2020, v. 126, n. 22, p. 4826, doi. 10.1002/cncr.33159
By:
- Friedlaender, Alex;
- Drilon, Alexander;
- Banna, Giuseppe Luigi;
- Peters, Solange;
- Addeo, Alfredo
Publication type:
Article
Clinical implications of drug‐induced liver injury in early‐phase oncology clinical trials.
Published in:
Cancer (0008543X), 2020, v. 126, n. 22, p. 4967, doi. 10.1002/cncr.33153
By:
- Mondaca, Sebastian P.;
- Liu, Dazhi;
- Flynn, Jessica R.;
- Badson, Sandy;
- Hamaway, Stefan;
- Gounder, Mrinal M.;
- Khalil, Danny N.;
- Drilon, Alexander E.;
- Li, Bob T.;
- Jhaveri, Komal L.;
- Schram, Alison M.;
- Kargus, Katherine E.;
- Kasler, Mary Kate;
- Blauvelt, Natalie M.;
- Segal, Neil H.;
- Capanu, Marinela;
- Callahan, Margaret K.;
- Hyman, David M.;
- Gambarin‐Gelwan, Maya;
- Harding, James J.
Publication type:
Article
Author Correction: Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.
Published in:
Nature Communications, 2018, v. 9, p. 16187, doi. 10.1038/ncomms16187
By:
- Cook, Peter J.;
- Thomas, Rozario;
- Kannan, Ram;
- de Leon, Esther Sanchez;
- Drilon, Alexander;
- Rosenblum, Marc K.;
- Scaltriti, Maurizio;
- Benezra, Robert;
- Ventura, Andrea
Publication type:
Article
Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.
Published in:
Nature Communications, 2017, v. 8, n. 7, p. 15987, doi. 10.1038/ncomms15987
By:
- Cook, Peter J.;
- Thomas, Rozario;
- Kannan, Ram;
- de Leon, Esther Sanchez;
- Drilon, Alexander;
- Rosenblum, Marc K.;
- Scaltriti, Maurizio;
- Benezra, Robert;
- Ventura, Andrea
Publication type:
Article
Phase I study of lurbinectedin in combination with weekly paclitaxel with or without bevacizumab in patients with advanced solid tumors.
Published in:
Investigational New Drugs, 2022, v. 40, n. 6, p. 1263, doi. 10.1007/s10637-022-01281-z
By:
- Calvo, Emiliano;
- Sessa, Cristiana;
- Harada, Guilherme;
- de Miguel, Maria;
- Kahatt, Carmen;
- Luepke-Estefan, Xarles Erik;
- Siguero, Mariano;
- Fernandez-Teruel, Carlos;
- Cullell-Young, Martin;
- Stathis, Anastasios;
- Drilon, Alexander
Publication type:
Article
A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN deficient tumors and with dose intensified carboplatin and paclitaxel.
Published in:
Investigational New Drugs, 2017, v. 35, n. 6, p. 742, doi. 10.1007/s10637-017-0445-0
By:
- Smyth, Lillian;
- Monson, Kelsey;
- Jhaveri, Komal;
- Drilon, Alexander;
- Li, Bob;
- Abida, Wassim;
- Iyer, Gopa;
- Gerecitano, John;
- Gounder, Mrinal;
- Harding, James;
- Voss, Martin;
- Makker, Vicky;
- Ho, Alan;
- Razavi, Pedram;
- Iasonos, Alexia;
- Bialer, Philip;
- Lacouture, Mario;
- Teitcher, Jerrold;
- Erinjeri, Joseph;
- Katabi, Nora
Publication type:
Article
The activity, safety, and evolving role of brigatinib in patients with ALK-rearranged non-small cell lung cancers.
Published in:
OncoTargets & Therapy, 2017, v. 10, p. 1983, doi. 10.2147/OTT.S109295
By:
- Sabari, Joshua K.;
- Santini, Fernando C.;
- Schram, Alison M.;
- Bergagnini, Isabella;
- Ruqin Chen;
- Mrad, Chebli;
- Lai, W. Victoria;
- Arbour, Kathryn C.;
- Drilon, Alexander
Publication type:
Article
Characterization, management, and risk factors of hyperglycemia during PI3K or AKT inhibitor treatment.
Published in:
Cancer Medicine, 2022, v. 11, n. 8, p. 1796, doi. 10.1002/cam4.4579
By:
- Liu, Dazhi;
- Weintraub, Michael A.;
- Garcia, Christine;
- Goncalves, Marcus D.;
- Sisk, Ann Elizabeth;
- Casas, Alissa;
- Harding, James J.;
- Harnicar, Stephen;
- Drilon, Alexander;
- Jhaveri, Komal;
- Flory, James H.
Publication type:
Article
Pre- and post-treatment blood-based genomic landscape of patients with ROS1 or NTRK fusion-positive solid tumours treated with entrectinib.
Published in:
Molecular Oncology, 2022, v. 16, n. 10, p. 2000, doi. 10.1002/1878-0261.13214
By:
- Dziadziuszko, Rafal;
- Hung, Tiffany;
- Kun Wang;
- Choeurng, Voleak;
- Drilon, Alexander;
- Doebele, Robert C.;
- Barlesi, Fabrice;
- Wu, Charlie;
- Dennis, Lucas;
- Skoletsky, Joel;
- Woodhouse, Ryan;
- Meijuan Li;
- Ching-Wei Chang;
- Simmons, Brian;
- Riehl, Todd;
- Wilson, Timothy R.
Publication type:
Article
Clinical and Morphologic Characteristics of Fibroblast Growth Factor Receptor Inhibitor-Associated Retinopathy.
Published in:
2021
By:
- Francis, Jasmine H.;
- Harding, James J.;
- Schram, Alison M.;
- Canestraro, Julia;
- Haggag-Lindgren, Dianna;
- Heinemann, Murk;
- Kriplani, Anuja;
- Jhaveri, Komal;
- Voss, Martin H.;
- Bajorin, Dean;
- Abou-Alfa, Ghassan K.;
- Iyer, Gopa;
- Drilon, Alexander;
- Rosenberg, Jonathan;
- Abramson, David H.
Publication type:
journal article
Rationale and design of ON-TRK: a novel prospective non-interventional study in patients with TRK fusion cancer treated with larotrectinib.
Published in:
2022
By:
- Yang, James C. H.;
- Brose, Marcia S.;
- Castro, Gilberto;
- Kim, Edward S.;
- Lassen, Ulrik N.;
- Leyvraz, Serge;
- Pappo, Alberto;
- López-Ríos, Fernando;
- Reeves, John A.;
- Fellous, Marc;
- Penault-Llorca, Frédérique;
- Rudzinski, Erin R.;
- Tabatabai, Ghazaleh;
- Vassal, Gilles;
- Drilon, Alexander;
- Trent, Jonathan
Publication type:
journal article
Entrectinib: an orally available, selective tyrosine kinase inhibitor for the treatment of NTRK, ROS1, and ALK fusion-positive solid tumors.
Published in:
Therapeutics & Clinical Risk Management, 2018, v. 14, p. 1247, doi. 10.2147/TCRM.S147381
By:
- Liu, Dazhi;
- Offin, Michael;
- Harnicar, Stephen;
- Li, Bob T;
- Drilon, Alexander
Publication type:
Article
Decision‐making as discovery: Vetting clinical research in a leading precision oncology service.
Published in:
Sociology of Health & Illness, 2024, v. 46, n. 3, p. 495, doi. 10.1111/1467-9566.13719
By:
- Cambrosio, Alberto;
- Campbell, Jonah;
- Drilon, Alexander E.;
- Keating, Peter;
- Polk, Jess B.
Publication type:
Article
Changing the Therapeutic Landscape in Non-small Cell Lung Cancers: the Evolution of Comprehensive Molecular Profiling Improves Access to Therapy.
Published in:
Current Oncology Reports, 2017, v. 19, n. 4, p. 1, doi. 10.1007/s11912-017-0587-4
By:
- Sabari, Joshua;
- Santini, Fernando;
- Bergagnini, Isabella;
- Lai, W.;
- Arbour, Kathryn;
- Drilon, Alexander
Publication type:
Article
Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma.
Published in:
European Journal of Endocrinology, 2022, v. 186, n. 6, p. 631, doi. 10.1530/eje-21-1259
By:
- Waguespack, Steven G.;
- Drilon, Alexander;
- Lin, Jessica J.;
- Brose, Marcia S;
- McDermott, Ray;
- Almubarak, Mohammed;
- Bauman, Jessica;
- Casanova, Michela;
- Krishnamurthy, Anuradha;
- Kummar, Shivaani;
- Leyvraz, Serge;
- Do-Youn Oh;
- Park, Keunchil;
- Sohal, Davendra;
- Sherman, Eric;
- Norenberg, Ricarda;
- Silvertown, Josh D.;
- Brega, Nicoletta;
- Hong, David S.;
- Cabanillas, Maria E.
Publication type:
Article

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