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- Title
Is there a relationship between hematological inflammatory parameters and age-related macular degeneration?
- Authors
Karahan, Mine; Hazar, Leyla; Erdem, Seyfettin; Ava, Sedat; Dursun, Mehmet Emin; Demirtaş, Atılım Armağan; Keklikçi, Uğur
- Abstract
Purpose: We aimed to analyze blood inflammation parameters in patients with age-related macular degeneration (AMD). Methods: In this retrospective study, patients were divided into three groups: wet-type AMD (n = 60), dry-type AMD (n = 60), and healthy controls (n = 71). The laboratory and demographic data of the patients were analyzed. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were calculated manually. Results: The mean NLR was 2.26 ± 1.42 in the dry-type AMD group, 3.90 ± 1.65 in the wet-type AMD group, and 1.84 ± 0.61 in the control group (p < 0.001). The mean MLR was 0.30 ± 0.20 in the dry-type AMD group, 0.47 ± 0.31 in the wet-type AMD group, and 0.28 ± 0.14 in the control group (p < 0.001). The mean PLR was 129.31 ± 79.82 in the dry-type AMD group, 156.67 ± 83.99 in the wet-type AMD group, and 135.59 ± 58.68 in the control group (p = 0.101). Receiver operating characteristic (ROC) curve analyses revealed that the area under the curve (AUC) for NLR and MLR was 0.920 and 0.717, respectively, for wet-type AMD. The sensitivity and specificity of NLR for wet-type AMD were 64% and 93%, respectively, whereas MLR was 63% and 75%, respectively. Conclusion: Simple blood tests revealed that NLR and MLR were significantly higher in patients with wet-type AMD than in patients with dry-type AMD and healthy controls, which implies low-grade inflammation.
- Subjects
DISEASE risk factors; RETINAL degeneration; BIOMARKERS; INFLAMMATION; BLOOD platelets; RETROSPECTIVE studies; RISK assessment; NEUTROPHILS; LYMPHOCYTES; DESCRIPTIVE statistics; RECEIVER operating characteristic curves; MONOCYTES
- Publication
Therapeutic Advances in Ophthalmology, 2021, p1
- ISSN
2515-8414
- Publication type
Article
- DOI
10.1177/25158414211010550