The article discusses research on phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PI3KCA) mutations in colorectal cancer. Topics discussed include phosphatidylinositol-3, 4, 5-triphosphate (PIP3), epithelial growth factor receptor (EGFR), and vascular EGFR (VEGFR). Also mentioned are cell growth, protein synthesis, and receptor tyrosine kinases.