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- Title
6-18 Yaş Arası Çocuklarda Nütrisyonel Vitamin B<sub>12</sub> Eksikliğinde Oral Kobalamin Tedavisinin Etkinliğinin Retrospektif Değerlendirilmesi.
- Authors
PEHLİVAN, Ali; ERDURAN, Erol; BAHADIR, Ayşenur; REİS, Gökçe Pınar
- Abstract
Objective: Orally administered vitamin B12 treatment is a more suitable option for children to adapt to the treatment. In this study, it was aimed to retrospectively evaluate the effectiveness of oral vitamin B12 treatment [cyanocobalamin (Dodex ampoule)® 1,000 µg/amp, orally on an empty stomach, 1,000 µg every day for the first week, 1,000 µg every other day for the next week, then 1,000 µg twice a week for two weeks, then 1,000 µg once a week for 4 months oral B12 maintenance therapy] conducted on children aged 6-18 years with nutritional vitamin B12 deficiency. Material and Methods: The files of 6-18 age group patients who were followed up and treated with the diagnosis of vitamin B12 deficiency at Karadeniz Technical University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Hematology and Oncology between January 2010 and January 2018 were analyzed retrospectively. Results: The most common complaint was: headache (28.8%). Patients were diagnosed with high red cell distribution width in 24.1%, anemia in 18.8%, lymphopenia in 7.5%, macrocytosis in 3.1%, neutropenia in 2.8% and thrombocytopenia in 2.7%. Homocysteine elevation was found in 30.1% and urinary methylmalonic acid elevation in 15.6% of the patients. Serum vitamin B12 levels which are evaluated after treatment and hemoglobin values increased. Although these values were found to be significantly higher (p<0.05) compared to the values before the treatment, the mean serum B12 levels were 191.4 pg/mL (<200 pg/mL). In maintenance treatment, the success rate of 1,000 mcg cyanocobalamin treatment given for 4 months, once-a-week was 27.7%. Conclusion: Although oral treatment is effective, it has been concluded that a 4-month, once-a-week maintenance treatment is not sufficient in 6-18 age group patients. Therefore, we believe that it will be more appropriate to offer an oral vitamin B12 maintenance treatment more frequently than once a week.
- Subjects
VITAMIN deficiency; METHYLMALONIC acid; ORAL drug administration; ERYTHROCYTES; PEDIATRIC hematology; RED blood cell transfusion; LYMPHOPENIA
- Publication
Turkiye Klinikleri Journal of Pediatrics / Türkiye Klinikleri Pediatri Dergisi, 2023, Vol 32, Issue 1, p8
- ISSN
1300-0381
- Publication type
Article
- DOI
10.5336/pediatr.2022-91251