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- Title
Eosinophilia - associated basal plasmacytosis: an early and sensitive histologic feature of inflammatory bowel disease.
- Authors
Canavese, Gabriella; Villanacci, Vincenzo; Antonelli, Elisabetta; Cadei, Moris; Sapino, Anna; Rocca, Rodolfo; Daperno, Marco; Suriani, Renzo; Di santo, Maria Giulia; Cassoni, Paola; Bernardini, Nunzia; Bassotti, Gabrio
- Abstract
Basal plasmacytosis is an early-onset and highly predictive feature of inflammatory bowel disease ( IBD), but may have several restrictions in routine histology. Considering evidences about cooperation between eosinophils and plasma cells in IBD pathogenesis, we investigated immunostain of these two cells as a marker of disease. 343 samplings from 83 patients (52 IBD, 31 non- IBD colitis) were evaluated. The sections were stained with monoclonal antibodies against plasma cells ( CD138 and MUM1), and eosinophils ( CD193). Eosinophilia-associated basal plasmacytosis ( EBP) was related with the histologic diagnosis of IBD (90.3% IBD and 35.4% non- IBD colitides, p < 0.005, sensitivity 90.4%). A strong relation was detected between the occurrence of EBP and (i) the achieving of a complete endoscopic mapping; (ii) the presence of other characteristic lesions of IBD in single segmental sampling, although EBP was evident in more than 40% of samples without other IBD-related lesions. EBP is a sensitive histologic feature of IBD, especially at the first endoscopic sampling, even in the absence of the other characteristic histologic lesions, and may help in formulating a more precise diagnosis in this setting.
- Subjects
EOSINOPHILIA; MINK Aleutian disease; INFLAMMATORY bowel diseases; EOSINOPHILS; PLASMA cells; CARCINOGENESIS; IMMUNOHISTOCHEMISTRY
- Publication
APMIS, 2017, Vol 125, Issue 3, p179
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/apm.12639