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- Title
Preparation and Performance Study of a New Cinchonine-Based Catalyst.
- Authors
Zhan, Murong; Wang, Zixuan; Yang, Yu; Li, Chonglong
- Abstract
Using cinchonine as a raw material, a cinchonine-based isonitrile monomer was prepared after multistep transformation, and finally cinchonine-based catalyst was prepared by polymerization initiated by 4-methoxyphenylethynyl(chloro)bis(triethylphosphine)palladium(II). The new catalyst was used to catalyze asymmetric aldol reactions between cyclohexanone and aromatic aldehydes with different substituent groups. The reaction of cyclohexanone and 3-nitrobenzaldehyde in methanol afforded an enantiomeric excess (ee) value of up to 55% and a diastereomeric ratio (dr) of up to 30:70, indicating high performance of the catalyst. The synthesized compounds were characterized by HPLC, IR, and 1H NMR.
- Subjects
ALDOLS; CATALYSTS; PERFORMANCE theory; CHEMICAL synthesis; AROMATIC aldehydes; CYCLOHEXANONES; RAW materials
- Publication
Russian Journal of Organic Chemistry, 2024, Vol 60, Issue 3, p495
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428024030187