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- Title
High-Risk Acute Myeloid Leukemia: A Pediatric Prospective.
- Authors
Cacace, Fabiana; Iula, Rossella; De Novellis, Danilo; Caprioli, Valeria; D'Amico, Maria Rosaria; De Simone, Giuseppina; Cuccurullo, Rosanna; Wierda, William G.; Mahadeo, Kris Michael; Menna, Giuseppe; Tambaro, Francesco Paolo
- Abstract
Pediatric acute myeloid leukemia is a clonal disorder characterized by malignant transformation of the hematopoietic stem cell. The incidence and the outcome remain inferior when compared to pediatric ALL, although prognosis has improved in the last decades, with 80% overall survival rate reported in some studies. The standard therapeutic approach is a combined cytarabine and anthracycline-based regimen followed by consolidation with allogeneic stem cell transplantation (allo-SCT) for high-risk AML and allo-SCT for non-high-risk patients only in second complete remission after relapse. In the last decade, several drugs have been used in clinical trials to improve outcomes in pediatric AML treatment.
- Subjects
ACUTE myeloid leukemia; HEMATOPOIETIC stem cells; STEM cell transplantation; THERAPEUTICS; PEDIATRIC therapy
- Publication
Biomedicines, 2022, Vol 10, Issue 6, p1405
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines10061405