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- Title
Alteration of Neural Pathways and Its Implications in Alzheimer's Disease.
- Authors
Kim, Sujin; Nam, Yunkwon; Kim, Hyeon soo; Jung, Haram; Jeon, Seong Gak; Hong, Sang Bum; Moon, Minho
- Abstract
Alzheimer's disease (AD) is a neurodegenerative disease accompanied by cognitive and behavioral symptoms. These AD-related manifestations result from the alteration of neural circuitry by aggregated forms of amyloid-β (Aβ) and hyperphosphorylated tau, which are neurotoxic. From a neuroscience perspective, identifying neural circuits that integrate various inputs and outputs to determine behaviors can provide insight into the principles of behavior. Therefore, it is crucial to understand the alterations in the neural circuits associated with AD-related behavioral and psychological symptoms. Interestingly, it is well known that the alteration of neural circuitry is prominent in the brains of patients with AD. Here, we selected specific regions in the AD brain that are associated with AD-related behavioral and psychological symptoms, and reviewed studies of healthy and altered efferent pathways to the target regions. Moreover, we propose that specific neural circuits that are altered in the AD brain can be potential targets for AD treatment. Furthermore, we provide therapeutic implications for targeting neuronal circuits through various therapeutic approaches and the appropriate timing of treatment for AD.
- Subjects
NEURAL pathways; ALZHEIMER'S disease; EFFERENT pathways; NEURAL circuitry; NEURODEGENERATION
- Publication
Biomedicines, 2022, Vol 10, Issue 4, p845
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines10040845