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- Title
Percutaneous permeability of lidocaine hydrochloride loaded destran-based niosomes.
- Authors
NIU Jiao; ZENG Dong; LI Qin; WANG Sheng; CHANG Jin; WANG Yue; ZHANG Lianyun
- Abstract
Objective To study the percutaneous permeability through mouse skin of lidocaine hydrochloride-loaded destran-based niosomes (LID-HLD-BNs)in vitro and in vivo. Methods HPLC was employed to exam lidocaine hydrochloride. Lidocaine hydro-chloride-loaded conventional liposomes (LID-CLs) and lidocaine hydrochloride injection (LID-IJ) were used as control. Isolated mouse skin was added into Franz diffusion cell to evaluate the permeability of LID-HLD-BNs in vitro. Confocal Laser Scanning Microscopy (CLSM)was used to observe the permeation depth of mouse skin in vivo. Results The permeation rate and cumulative permeation amount were significantly higher in LID-HLD-BNs group than those of LID-CLs and LID-IJ groups (P<0.05). CLSM studies also confirmed that HLD-BNs reached deeper layers of the skin. Conclusion LID-HLD-BNs has good transdermal ability.
- Subjects
SKIN permeability; VESICLES (Cytology); LIDOCAINE; HIGH performance liquid chromatography; CONFOCAL microscopy; LABORATORY mice
- Publication
Tianjin Medical Journal, 2015, Vol 43, Issue 4, p353
- ISSN
0253-9896
- Publication type
Article
- DOI
10.11958/j.issn.0253-9896.2015.04.005