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- Title
Correlation between blood lipids level with creatinine clearance rate in patients with heart failure.
- Authors
ZHAO Yuanyuan; WANG Lin; SONG Fang; LIU Qingjun; HUA Rong; LONG Dan; YANG Limin; LIU Bainian
- Abstract
Objective To explore the relationship between blood lipids level with creatinine clearance rate (Ccr) in patients with heart failure (HF). Methods A total of 955 patients who were diagnosed with heart failure (cardiac function NYHA II~IV classification) upon discharge from the Department of Cardiology of the Second Hospital of Tianjin Medical University, between January 2010 to June 2013 were enrolled as HF group. Healthy adults (n=200) with normal cardiac function which approximately matched basic condition with HF group were selected as control group. The HF group was further divided into II, III, IV classification according to their cardiac function (NYHA classification). HF group was also divided into normal renal function group, mild renal injury group and moderate-severe renal injury group based on their Ccr. Effect of gender and lipid parameters were also compared. Binary logistic regression was used to analyze factors influencing renal function in patients with HF. Results Compared with people in the control group, the levels of triacylglycerol (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c) and non high density lipoprotein cholesterol (non-HDLc) in patients of HF group were increased while Ccr and high density lipoprotein cholesterol (HDL-c)were decreased. Ccr and lipids were obviously decreased in patients with HF of IV classification. TG and HDL-c were decreased in moderatesevere renal injury group. Females had a higher lipid levels than males in HF group (P < 0.05 or P < 0.01). Advanced age, coronary heart disease and hypertension were all risk factors for renal impairment in patients with HF by binary logistic regression. On the other hand, weight gain and HDL-c were the protection factors for renal function in HF patients. Conclusion Dyslipidemias may lead to renal insufficiency in patients with HF. It was important to control lipids and improve renal function in patients with HF.
- Subjects
BLOOD lipids; CREATININE; HEART failure patients; TRIGLYCERIDES; BLOOD cholesterol; LOW density lipoproteins; HIGH density lipoproteins; LOGISTIC regression analysis
- Publication
Tianjin Medical Journal, 2015, Vol 43, Issue 4, p408
- ISSN
0253-9896
- Publication type
Article
- DOI
10.11958/j.issn.0253-9896.2015.04.020