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- Title
Advances in Studies on the Effect of Incretin-Based Therapy on Cardiovascular System.
- Authors
YU Qian; YU Demin
- Abstract
Cardiovascular disease (CVD) is one of the major complications of type 2 diabetes mellitus (T2DM), which results in a high risk of mortality. Thus, the cardiovascular safety of new anti-diabetic agents has become an important problem with wide concern. There are two classes of incretine- based medications: glucagon- like peptide- 1 receptor agonist (GLP-1RA) and dipeptidyl peptidase-4 (DPP-4) inhibitor (DPP-4I). It has been demonstrated that GLP-1RA and DPP-4I possesse beneficial actions in both animal models of cardiovascular dysfunction and patients with ischemic heart diseases. However, their effects on the cardiovascular system in diabetic patients with heart diseases are still uncertain. Here, we systematically reviewed the effects of GLP-1RA and DPP-4I on cardiovascular system to provide more evidence of incretinbased therapy application for diabetes and complications.
- Subjects
INCRETINS; CARDIOVASCULAR disease treatment; TYPE 2 diabetes complications; GLUCAGON-like peptide 1; PEPTIDASE; THERAPEUTICS
- Publication
Tianjin Medical Journal, 2014, Vol 42, Issue 11, p1144
- ISSN
0253-9896
- Publication type
Article
- DOI
10.3969/j.issn.0253-9896.2014.11.028