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- Title
Increased cardiac output, not pulmonary artery systolic pressure, increases intrapulmonary shunt in healthy humans breathing room air and 40% O<sub>2</sub>.
- Authors
Elliott, Jonathan E.; Duke, Joseph W.; Hawn, Jerold A.; Halliwill, John R.; Lovering, Andrew T.
- Abstract
Key points The contribution of blood flow through intrapulmonary arteriovenous anastomoses (IPAVAs) to pulmonary gas exchange efficiency remains unknown and controversial., Intravenous infusion of adrenaline (epinephrine) increases blood flow through IPAVAs detected by the transpulmonary passage of saline contrast and breathing 40% O2 minimizes potential contributions from ventilation-to-perfusion inequality and diffusion limitation., Pulmonary gas exchange efficiency was impaired to the same degree, and the transpulmonary passage of saline contrast was not different, in humans at rest during the intravenous infusion of adrenaline before and after atropine when breathing room air and 40% O2., Cardiac output increased to the same degree during intravenous infusion of adrenaline before and after atropine, but pulmonary artery systolic pressure only increased significantly before atropine., These data demonstrate that blood flow through IPAVAs contributes to pulmonary gas exchange efficiency and that blood flow through IPAVAs is predominantly mediated by increases in cardiac output rather than increases in pulmonary artery systolic pressure., Abstract Blood flow through intrapulmonary arteriovenous anastomoses (IPAVAs) has been demonstrated to increase in healthy humans during a variety of conditions; however, whether or not this blood flow represents a source of venous admixture (
- Subjects
BLOOD flow; CARDIAC output; SYSTOLIC blood pressure; PULMONARY gas exchange; ADRENALINE; ATROPINE
- Publication
Journal of Physiology, 2014, Vol 592, Issue 20, p4537
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2014.274829