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- Title
Termitomenins F and G, Two New Lignan Glucosides from Terminalia chebula var. tomentella (Kurz) C. B. Clarke.
- Authors
Yin, Jun; Zhu, Hong-Tao; Zhang, Man; Wang, Dong; Yang, Chong-Ren; Zhang, Ying-Jun
- Abstract
The extensive chemical investigation on the branches and leaves of Terminalia chebula var. tomentella (Combretaceae) led to the isolation of two new lignan glucosides with a furofuran skeleton, termitomenins F (1) and G (2). In addition, 19 known compounds including five lignan glucosides (3–7), six hydrolyzable tannins (8–13) and eight simple phenolics (14–21) were also identified. Their structures were determined by comprehensive spectroscopic analyses. It is noted that 8 and 9 were C-glycosidic hydrolyzable tannins with one hexahydroxydiphenoyl and one gallagyl group linked to an open-chain glucosyl C-1/O-2/O-3 and O-4/O-6, respectively, which were rarely found in plants. Nine known compounds, 6–9, 13, and 18–21, were procured from the titled plant for the first time, while 3–5, 10–12 and 14–17 were also found in the fruits. Notably, the known hydrolyzable tannins 8–13 exhibited stronger α-glucosidase inhibitory activities with IC50 values ranging from 0.10 to 3.12 μM, than the positive control, quercetin (IC50 = 9.38 ± 0.33 μM).
- Subjects
TERMINALIA chebula; GLUCOSIDES; TANNINS; QUERCETIN; PHENOLS; COMBRETACEAE
- Publication
Natural Products & Bioprospecting, 2021, Vol 11, Issue 5, p565
- ISSN
2192-2209
- Publication type
Article
- DOI
10.1007/s13659-021-00314-z