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- Title
Carotid ultrasound examination as an aging and disability marker.
- Authors
Barrera, Gladys; Bunout, Daniel; Maza, María Pía; Leiva, Laura; Hirsch, Sandra
- Abstract
Aim To explore the usefulness of carotid ultrasound examination as a marker of aging and predictor of disability among older people. Methods Carotid ultrasound, measuring carotid intima media thickness ( CIMT) and recording the presence of plaques, was carried out in 152 adults aged 29-59 years (47 women) and in 107 older adults aged 61-88 years (86 women). In all, clinical routine laboratory parameters and lymphocyte telomere length as T/ S ratio were measured. Among older adults, 12-min walk, timed up and go, hand grip and quadriceps strength were determined. Results CIMT was significantly higher among older people and T/ S ratio was significantly higher in young women. Carotid plaques were found in one adult and 17 older people. A multiple regression analysis accepted age, systolic blood pressure and T/ S ratios as independent predictors of CIMT ( R2 = 0.51). Among older people, a logistic regression accepted age and the presence of carotid plaques as significant predictors of a 12-min walk speed below 1 m/s. Conclusions An abnormal 12-min walk as an indicator of functional decline among older people is associated with the presence of carotid artery plaques. CIMT is independently associated with age. Geriatr Gerontol Int 2014; 14: 710-715.
- Subjects
CHILE; CHROMOSOME analysis; WALKING; PHYSICAL fitness; AGING; BIOMARKERS; BLOOD pressure; BODY composition; CAROTID artery; CHI-squared test; COMPARATIVE studies; CONFIDENCE intervals; STATISTICAL correlation; CLINICAL pathology; GRIP strength; NEUROPSYCHOLOGICAL tests; PEOPLE with disabilities; REGRESSION analysis; RESEARCH funding; SEX distribution; STATISTICS; DATA analysis; MULTIPLE regression analysis; PREDICTIVE validity; DESCRIPTIVE statistics; ODDS ratio
- Publication
Geriatrics & Gerontology International, 2014, Vol 14, Issue 3, p710
- ISSN
1444-1586
- Publication type
Article
- DOI
10.1111/ggi.12146