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- Title
Calcitriol for bone loss in patients with primary biliary cirrhosis.
- Authors
Shiomi, Susumu; Masaki, Kyoko; Habu, Daiki; Takeda, Tadashi; Nishiguchi, Shuhei; Kuroki, Tetsuo; Ochi, Hironobu; Shiomi, S; Masaki, K; Habu, D; Takeda, T; Nishiguchi, S; Kuroki, T; Ochi, H
- Abstract
Because osteoporosis is a common complication of primary biliary cirrhosis, we evaluated the effects of calcitriol (1alpha, 25-dihydroxyvitamin D3) on bone mineral density in 34 women with primary biliary cirrhosis (stage I disease in 16 patients, stage II in 9, stage III in 4, and stage IV in 5). Patients were assigned randomly to receive calcitriol (0.5mg twice a day) or not. Bone mineral density of the lumbar vertebrae was measured by dual-energy X-ray absorptiometry at least twice during a period of 12-43 months. The mean annual change in bone mineral density was 0.1% in the treatment group and -3.1% in the control group. The median annual change (with 25th and 75th percentiles) in bone mineral density was 0.3% (-0.5%, 1.9%) in the treated group and -3.1% (-4.1%, -2.1%) in the control group. This difference between the two groups was significant (P = 0.0007, Mann-Whitney U-test). Our findings suggest that calcitriol prevents bone loss and may be an effective treatment for osteoporosis in patients with primary biliary cirrhosis.
- Subjects
OSTEOPOROSIS treatment; CALCIUM; BONE densitometry; THERAPEUTICS; CALCITRIOL; CLINICAL trials; COMPARATIVE studies; CIRRHOSIS of the liver; RESEARCH methodology; MEDICAL cooperation; OSTEOPOROSIS; REGRESSION analysis; RESEARCH; TIME; EVALUATION research; BONE density; RANDOMIZED controlled trials; PHOTON absorptiometry; DISEASE complications
- Publication
Journal of Gastroenterology, 1999, Vol 34, Issue 2, p241
- ISSN
0944-1174
- Publication type
journal article
- DOI
10.1007/s005350050250