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- Title
Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development.
- Authors
Jennum, Poul; Christensen, Julie A. E.; Zoetmulder, Marielle
- Abstract
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by a history of recurrent nocturnal dream enactment behavior and loss of skeletal muscle atonia and increased phasic muscle activity during REM sleep: REM sleep without atonia. RBD and associated comorbidities have recently been identified as one of the most specific and potentially sensitive risk factors for later development of any of the alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and other atypical parkinsonian syndromes. Several other sleep-related abnormalities have recently been identified in patients with RBD/ Parkinson's disease who experience abnormalities in sleep electroencephalographic frequencies, sleep-wake transitions, wake and sleep stability, occurrence and morphology of sleep spindles, and electrooculography measures. These findings suggest a gradual involvement of the brainstem and other structures, which is in line with the gradual involvement known in these disorders. We propose that these findings may help identify biomarkers of individuals at high risk of subsequent conversion to parkinsonism.
- Subjects
RAPID eye movement sleep; DRUG development; SKELETAL muscle; PARKINSON'S disease; ELECTROENCEPHALOGRAPHY; SLEEP-wake cycle; PHYSIOLOGY
- Publication
Nature & Science of Sleep, 2016, Vol 8, p107
- ISSN
1179-1608
- Publication type
Article
- DOI
10.2147/NSS.S99240