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- Title
Autologous stem cell transplantation using modified TAM or combination of triple-alkylating agents conditioning regimens as one of the post-remission treatments in patients with adult acute myeloid leukemia in first complete remission.
- Authors
Kim, H-J.; Min, W-S.; Eom, K-S.; Park, S-J.; Park, Y-H.; Kim, D-W.; Lee, J-W.; Park, C-W.; Kim, C-C.
- Abstract
Summary:A total of 174 newly diagnosed adult acute myeloid leukaemia (AML) patients were treated in first complete remission (CR1) using modified TAM or a combination of triple-alkylating agents followed by autologous transplantation (AT). Cytogenetic risk groups were classified and most patients received mobilized peripheral blood stem/progenitor cells (PBSCs). The infused cell dose consisted of a median of 4.1±2 (range, 1.2-17.1)× 106/kg CD34+ cells. With a median follow-up of 51 months (range, 5-131 months) after CR1, the estimated 5-year disease-free survival (DFS) rate was 68 (95% confidence interval (CI), 63-73%) and the event-free survival rate at 5 years was 59 (95% CI, 54-64%). AML patients other than M3 subtype, the long-term DFS rate was 76, 33% for favourable and unfavourable risk groups, respectively. In all, 40 patients had relapses (40/174, 23%) at the median 15 months after CR1 (range, 8-66 months). Overall, seven patients (4%) died in connection with AT. The infused CD34+ cell dose (P=0.0389) was associated with survival by multivariate analysis. In conclusion, two novel conditioning regimens in AT are feasible for adults with variable risk AML followed for over a 10-year period.Bone Marrow Transplantation (2004) 34, 215-220. doi:10.1038/sj.bmt.1704556 Published online 31 May 2004
- Subjects
AUTOTRANSPLANTATION; STEM cell transplantation; MYELOID leukemia; ALKYLATING agents; CARCINOGENS; TRANSPLANTATION of organs, tissues, etc.
- Publication
Bone Marrow Transplantation, 2004, Vol 34, Issue 3, p215
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1704556