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Development of Novel 4‐Arylpyridin‐2‐one and 6‐Arylpyrimidin‐4‐one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.
Published in:
ChemMedChem, 2021, v. 16, n. 1, p. 216, doi. 10.1002/cmdc.202000540
By:
- Jörg, Manuela;
- Khajehali, Elham;
- Westhuizen, Emma T.;
- C. Choy, K. H.;
- Shackleford, David M.;
- Tobin, Andrew B.;
- Sexton, Patrick M.;
- Valant, Celine;
- Capuano, Ben;
- Christopoulos, Arthur;
- Scammells, Peter J.
Publication type:
Article
Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias.
Published in:
Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.606656
By:
- van der Westhuizen, Emma T.;
- Choy, K. H. Christopher;
- Valant, Celine;
- McKenzie-Nickson, Simon;
- Bradley, Sophie J.;
- Tobin, Andrew B.;
- Sexton, Patrick M.;
- Christopoulos, Arthur
Publication type:
Article
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41199-5
By:
- Burger, Wessel A. C.;
- Pham, Vi;
- Vuckovic, Ziva;
- Powers, Alexander S.;
- Mobbs, Jesse I.;
- Laloudakis, Yianni;
- Glukhova, Alisa;
- Wootten, Denise;
- Tobin, Andrew B.;
- Sexton, Patrick M.;
- Paul, Steven M.;
- Felder, Christian C.;
- Danev, Radostin;
- Dror, Ron O.;
- Christopoulos, Arthur;
- Valant, Celine;
- Thal, David M.
Publication type:
Article
Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11062-7
By:
- Hollingsworth, Scott A.;
- Kelly, Brendan;
- Valant, Celine;
- Michaelis, Jordan Arthur;
- Mastromihalis, Olivia;
- Thompson, Geoff;
- Venkatakrishnan, A. J.;
- Hertig, Samuel;
- Scammells, Peter J.;
- Sexton, Patrick M.;
- Felder, Christian C.;
- Christopoulos, Arthur;
- Dror, Ron O.
Publication type:
Article
Investigating Drivers for M1 Muscarinic Acetylcholine Receptor‐Mediated Adverse Events by M1 Positive Allosteric Modulators.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2328
By:
- Nguyen, Huong T. M.;
- van der Westhuizen, Emma T.;
- Khajehali, Elham;
- Valant, Celine;
- Christopoulos, Arthur
Publication type:
Article
A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties.
Published in:
FASEB Journal, 2007, v. 21, n. 9, p. 2124, doi. 10.1096/fj.06-7683com
By:
- Maillet, Emeline L.;
- Pellegrini, Nadia;
- Valant, Celine;
- Bucher, Bernard;
- Hibert, Marcel;
- Bourguignon, Jean-Jacques;
- Galzi, Jean-Luc
Publication type:
Article
Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders.
Published in:
British Journal of Pharmacology, 2024, v. 181, n. 14, p. 2232, doi. 10.1111/bph.16023
By:
- Saito, Ayame;
- Alvi, Sadia;
- Valant, Celine;
- Christopoulos, Arthur;
- Carbone, Simona E.;
- Poole, Daniel P.
Publication type:
Article
Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor.
Published in:
British Journal of Pharmacology, 2024, v. 181, n. 14, p. 2338, doi. 10.1111/bph.16021
By:
- Jiang, Ye;
- Yeasmin, Mahmuda;
- Gondin, Arisbel B.;
- Christopoulos, Arthur;
- Valant, Celine;
- Burger, Wessel A. C.;
- Thal, David M.
Publication type:
Article
Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits.
Published in:
British Journal of Pharmacology, 2024, v. 181, n. 14, p. 2114, doi. 10.1111/bph.15982
By:
- Nguyen, Huong T. M.;
- van der Westhuizen, Emma T.;
- Langmead, Christopher J.;
- Tobin, Andrew B.;
- Sexton, Patrick M.;
- Christopoulos, Arthur;
- Valant, Celine
Publication type:
Article
Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Published in:
Nature, 2013, v. 504, n. 7478, p. 101, doi. 10.1038/nature12735
By:
- Kruse, Andrew C.;
- Ring, Aaron M.;
- Manglik, Aashish;
- Hu, Jianxin;
- Hu, Kelly;
- Eitel, Katrin;
- Hübner, Harald;
- Pardon, Els;
- Valant, Celine;
- Sexton, Patrick M.;
- Christopoulos, Arthur;
- Felder, Christian C.;
- Gmeiner, Peter;
- Steyaert, Jan;
- Weis, William I.;
- Garcia, K. Christopher;
- Wess, Jürgen;
- Kobilka, Brian K.
Publication type:
Article
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.
Published in:
Nature, 2013, v. 503, n. 7475, p. 295, doi. 10.1038/nature12595
By:
- Dror, Ron O.;
- Green, Hillary F.;
- Valant, Celine;
- Borhani, David W.;
- Valcourt, James R.;
- Pan, Albert C.;
- Arlow, Daniel H.;
- Canals, Meritxell;
- Lane, J. Robert;
- Rahmani, Raphaël;
- Baell, Jonathan B.;
- Sexton, Patrick M.;
- Christopoulos, Arthur;
- Shaw, David E.
Publication type:
Article

Found: 11

Development of Novel 4‐Arylpyridin‐2‐one and 6‐Arylpyrimidin‐4‐one Positive Allosteric Modulators of the M<sub>1</sub> Muscarinic Acetylcholine Receptor.

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias.

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M<sub>4</sub> mAChR.

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs.

Investigating Drivers for M<sub>1</sub> Muscarinic Acetylcholine Receptor‐Mediated Adverse Events by M<sub>1</sub> Positive Allosteric Modulators.

A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties.

Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders.

Importance of receptor expression in the classification of novel ligands at the M<sub>2</sub> muscarinic acetylcholine receptor.

Opportunities and challenges for the development of M<sub>1</sub> muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits.

Activation and allosteric modulation of a muscarinic acetylcholine receptor.

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.