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- Title
Left ventricular diastolic function in acute myocardial infarction.
- Authors
Smajić, Elnur; Kušljugić, Zumreta; Baraković, Fahir; Lončar, Daniela; Dizdarević-Hudić, Larisa; Kovačević, Katarina; Hadžović, Dani
- Abstract
Left ventricular (LV) diastolic disfunction is one of the first LV function abnormalities, which is detected before the regional disorder of contractility, ECG changes and chest pains, which significantly changes the prognosis of patients with acute coronary syndrome. The disorder of LV relaxation is often detected in patients with acute myocardial infarction (AMI), a disorder of LV stiffness in patients with anterior wall AMI. The most pronounced diastolic abnormality caused by myocardial ischemia is prolonged and delayed myocardial relaxation. Echocardiographic techniques allow the evaluation of diastolic filling of the both atria and ventricles. The aim of this study was to determine the LV diastolic function in patients with AMI and compare the diastolic function variables in the groups of patients with anteroseptal and inferior wall AMI. The prospective trial included 60 patients (37 men; mean age 59±10) with first AMI who were divided into two groups according to the localization of ECG changes (anteroseptal vs. inferior wall). LV diastolic function variables were monitored that were analyzed by continuous (mitral flow) and pulsed color Doppler echocardiography technique (flow in the pulmonary veins and mitral ring motions). The value of velocity of early diastolic filling was not statistically significantly different in the both groups, but it was lower compared to the average value of the velocity of the early diastolic filling of LV in healthy persons. In the maximum velocity of systolic pulmonary venous flow, a statistically significant difference was recorded (p<0.05) among the groups of patients. In the first group it was 0.48±0.10, while in the second group it was 0.57±0.14. Maximum velocity of diastolic pulmonary venous flow in the first group was 0.37±0.09, while in the second group it was 0.43±0.16. The ratio of maximum velocity of systolic and diastolic pulmonary venous flow was slightly higher than in healthy individuals. In patients with AMI, diastolic dysfunction of the LV relaxation disorder type prevails (70%). In the examined group of patients with anteroseptal AMI, diastolic dysfunction of the relaxation disorder type prevails, that is, a statistically significant difference compared to the normal diastolic function and diastolic dysfunction of the LV restriction disorder type (p<0.05) is recorded. Finally, in case of anteroseptal and inferior wall AMI, the parameters of diastolic function are changed, that is, all three degrees of LV diastolic dysfunction are present. Diastolic dysfunction of myocardial relaxation disorder type prevails. In anteroseptal wall AMI, diastolic dysfunction of relaxation disorder type is mostly present, that is in good correlation with infarcated zone in relation to the inferior wall.
- Subjects
LEFT heart ventricle diseases; DIASTOLE (Cardiac cycle); CHEST pain; ISCHEMIA; PULMONARY veins
- Publication
Kardio List, 2011, Vol 6, Issue 12, p383
- ISSN
1846-0836
- Publication type
Article