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- Title
Is Alcohol an independent risk factor for Oro-Pharyngeal and Pulmonary Carcinogenesis - An Acetaldehyde concentrations based Double Blinded Randomized Control Trial.
- Authors
Dagli, Rushabh J.; Kulkarni, Suhas; Duraiswamy, Prabu; Dagli, Namrata R.; Khara, Nimit V.; Khara, Birva N.
- Abstract
Background: There is increasing evidence that a major part of the tumour-promoting action of alcohol is mediated via its first, toxic and carcinogenic metabolite acetaldehyde. Materials & Methods: The double blinded randomized control trial was designed for 82 male volunteers aged 20- 29 years. Exclusion criteria were individual under antibiotic therapy, smokers, mutant Aldehyde Dehydrogenase deficient subject or any other systemic disease. Subjects were randomized in experimental (alcohol + soft drink) and control group (soft drink) from each pair of equal body weighted volunteers. The amount of alcohol consumed was calculated to be equivalent to 0.7 g alcohol/kilogram of body weight. Samples of breath for Acetaldehyde concentration (AC) were captured with the aid of a highly reproducible fuel cell gas-sampling device (PST-M1; Lions Laboratories, Cardiff, Wales). In Statistical analysis, mean AC was compared among both groups at different interval using paired t-test and Analysis of variance. Results: Mean acetaldehyde level was recorded higher (> 50.00 μmol/L) among interventional group which can be produced from ethanol during metabolism or by oro-pharyngeal microbes. After 15 minutes of drink, the AC was 71.36 ± 17.46 μmol/L in ethanol group compared to 22.75 ±9.12 μmol/L in soft-drink group. There was significant increase in AC after 1 hour (P<0.001) which was 77.58 ± 19.43 μmol/L in ethanol group compared to 21.16 ±8.73 μmol/L in soft-drink group. Conclusion: Although acetaldehyde is metabolite of alcohol, its organ specific production with risk for oropharyngeal and pulmonary carcinogenesis makes alcohol an independent risk factor of carcinogenesis.
- Subjects
ALCOHOLIC beverage research; PHYSIOLOGICAL effects of acetaldehyde; LUNG diseases -- Immunological aspects; CANCER immunology; PHARYNGEAL diseases
- Publication
Journal of International Oral Health, 2013, Vol 5, Issue 4, p62
- ISSN
0976-7428
- Publication type
Article