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- Title
Daily Practice Experience of Baricitinib Treatment for Patients with Difficult-to-Treat Atopic Dermatitis: Results from the BioDay Registry.
- Authors
BOESJES, Celeste M.; KAMPHUIS, Esmé; ZUITHOFF, Nicolaas P. A.; BAKKER, Daphne S.; LOMAN, Laura; SPEKHORST, Lotte S.; HAECK, Inge; KAMSTEEG, Marijke; VAN LYNDEN-VAN NES, Anneke M. T.; GARRITSEN, Floor M.; POLITIEK, Klaziena; OLDHOFF, Marja; DE GRAAF, Marlies; SCHUTTELAAR, Marie L. A.; DE BRUIN-WELLER, Marjolein S.
- Abstract
Clinical trials have shown that baricitinib, an oral selective Janus kinase 1/2 inhibitor, is effective for the treatment of moderate-to-severe atopic dermatitis. However, daily practice data are limited. Therefore, this multicentre prospective study evaluated the effectiveness and safety of 16-weeks' treatment with baricitinib in adult patients with moderate-to-severe atopic dermatitis in daily practice. A total of 51 patients from the BioDay registry treated with baricitinib were included and evaluated at baseline and after 4, 8 and 16 weeks of treatment. Effectiveness was assessed using clinician- and patient-reported outcome measurements. Adverse events and laboratory assessments were evaluated at every visit. At week 16, the probability (95% confidence interval) of achieving Eczema Area and Severity Index ≤ 7 and numerical rating scale pruritus ≤ 4 was 29.4% (13.1-53.5) and 20.5% (8.8-40.9), respectively. No significant difference in effectiveness was found between dupilumab non-responders and responders. Twenty-two (43.2%) patients discontinued baricitinib treatment due to ineffectiveness, adverse events or both (31.4%, 9.8% and 2.0%, respectively). Most frequently reported adverse events were nausea (n = 6, 11.8%), urinary tract infection (n = 5, 9.8%) and herpes simplex infection (n = 4, 7.8%). In conclusion, baricitinib can be an effective treatment option for moderate-to-severe atopic dermatitis, including patients with non-responsiveness on dupilumab. However, effectiveness of baricitinib is heterogeneous, which is reflected by the high discontinuation rate in this difficult-to-treat cohort.
- Subjects
ATOPIC dermatitis; BARICITINIB; HERPES simplex; URINARY tract infections; KINASE inhibitors; DUPILUMAB
- Publication
Acta Dermato-Venereologica, 2022, Vol 102, p1
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/actadv.v102.3978