We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System.
- Authors
Zhang, Isis; Hu, Huijuan
- Abstract
Store-operated calcium channels (SOCs) are widely expressed in excitatory and non-excitatory cells where they mediate significant store-operated calcium entry (SOCE), an important pathway for calcium signaling throughout the body. While the activity of SOCs has been well studied in non-excitable cells, attention has turned to their role in neurons and glia in recent years. In particular, the role of SOCs in the nervous system has been extensively investigated, with links to their dysregulation found in a wide variety of neurological diseases from Alzheimer's disease (AD) to pain. In this review, we provide an overview of their molecular components, expression, and physiological role in the nervous system and describe how the dysregulation of those roles could potentially lead to various neurological disorders. Although further studies are still needed to understand how SOCs are activated under physiological conditions and how they are linked to pathological states, growing evidence indicates that SOCs are important players in neurological disorders and could be potential new targets for therapies. While the role of SOCE in the nervous system continues to be multifaceted and controversial, the study of SOCs provides a potentially fruitful avenue into better understanding the nervous system and its pathologies.
- Subjects
ALZHEIMER'S disease; NEUROLOGICAL disorders; CALCIUM channels
- Publication
Frontiers in Cellular Neuroscience, 2020, Vol 14, pN.PAG
- ISSN
1662-5102
- Publication type
Article
- DOI
10.3389/fncel.2020.600758