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- Title
T Residues Preceded by Runs of G Are Hotspots of T→G Mutation in Bacteria.
- Authors
Cherry, Joshua L
- Abstract
The rate of mutation varies among positions in a genome. Local sequence context can affect the rate and has different effects on different types of mutation. Here, I report an effect of local context that operates to some extent in all bacteria examined: the rate of T→G mutation is greatly increased by preceding runs of three or more G residues. The strength of the effect increases with the length of the run. In Salmonella , in which the effect is strongest, a G run of length three 3 increases the rate by a factor of ∼26, a run of length 4 increases it by almost a factor of 100, and runs of length 5 or more increase it by a factor of more than 400 on average. The effect is much stronger when the T is on the leading rather than the lagging strand of DNA replication. Several observations eliminate the possibility that this effect is an artifact of sequencing error.
- Subjects
BACTERIAL mutation; DNA replication
- Publication
Genome Biology & Evolution, 2023, Vol 15, Issue 6, p1
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evad087