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- Title
Changes in hepatitis A virus seroepidemiology in HIV-infected Brazilian patients.
- Authors
Aloisse, R.; de Almeida, A. J.; Sion, F. S.; Morais-de-Sá, C. A.; Gaspar, A. M. C.; de Paula, V. S.
- Abstract
Shifting of hepatitis A virus (HAV) epidemiology from a high towards an intermediate endemicity pattern and use of antiretroviral therapy increased the risk of HIV/HAV coinfection in developing countries. The aim of this study was to investigate the presence of HAV markers in a cohort of HIV-infected patients from 1988 to 2004. The presence of serum anti-HAV antibodies and HAVRNA by real-time polymerase chain reaction was investigated in 581 patients. Total anti-HAV antibodies was found in 464/581 (79.8%) patients, however, achanging epidemiologic pattern of hepatitisAamongHIV-infected patients from1988 to 2004was observed.Among patients susceptible to HAV (n ¼ 117), 5 (4.2%) were coinfected with HAV, all of them had IgM anti-HAV antibodies and were serum HAVRNA- positive. The high prevalence of anti-HAV antibodies in HIV-infected patients suggests that screening tests for anti-HAV antibodies should be performed before implementation of hepatitis A vaccination, especially in those patients from endemic countries.
- Subjects
BRAZIL; HIV-positive persons; BRAZILIANS; HEPATITIS A; HEPATITIS A vaccines; ANTIRETROVIRAL agents; POLYMERASE chain reaction; IMMUNOGLOBULIN M; HIV antibodies; PREVENTION; DISEASES
- Publication
International Journal of STD & AIDS, 2008, Vol 19, Issue 5, p321
- ISSN
0956-4624
- Publication type
Article
- DOI
10.1258/ijsa.2007.007100