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- Title
Antiretroviral drug-resistant HIV-2 infection - a new therapeutic dilemma.
- Authors
Maniar JK; Damond F; Kamath RR; Mandalia S; Surjushe A
- Abstract
HIV-2 drug resistance in a case of dual HIV infection presents a formidable challenge to the treating physician. We report a patient with dual infection on highly active antiretroviral therapy (HAART) since March 2001 presented with clinical failure. Laboratory assays showed undetectable HIV-1 viral RNA copies, but with low CD4 count. Suspecting HIV-2 resistance, specific genotype assays were performed. Mutations at codons M184V and Q151M conferring resistance to nucleoside reverse transcriptase inhibitors (NRTIs) in HIV-1 infection were detected, as were mutations at codons V71I and L90M implying indinavir and nelfinavir resistance as well. Salvage therapy was initiated with good clinical response.
- Publication
International Journal of STD & AIDS, 2006, Vol 17, Issue 11, p781
- ISSN
0956-4624
- Publication type
Journal Article
- DOI
10.1258/095646206778691059