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- Title
Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders.
- Authors
Caminski, Emanuelle Sistherenn; Antunes, Flavia Tasmin Techera; Souza, Ivana Assis; Dallegrave, Eliane; Zamponi, Gerald W.
- Abstract
Activation of nociceptin opioid peptide receptors (NOP, a.k.a. opioid-like receptor-1, ORL-1) by the ligand nociceptin/orphanin FQ, leads to G protein-dependent regulation of Cav2.2 (N-type) voltage-gated calcium channels (VGCCs). This typically causes a reduction in calcium currents, triggering changes in presynaptic calcium levels and thus neurotransmission. Because of the widespread expression patterns of NOP and VGCCs across multiple brain regions, the dorsal horn of the spinal cord, and the dorsal root ganglia, this results in the alteration of numerous neurophysiological features. Here we review the regulation of N-type calcium channels by the NOP-nociceptin system in the context of neurological conditions such as anxiety, addiction, and pain.
- Subjects
CALCIUM channels; NOCICEPTIN; NEUROLOGICAL disorders; DORSAL root ganglia; PEPTIDE receptors; OPIOID receptors; G protein coupled receptors
- Publication
Molecular Brain, 2022, Vol 15, Issue 1, p1
- ISSN
1756-6606
- Publication type
Article
- DOI
10.1186/s13041-022-00982-z