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- Title
GONADAL HORMONE INDEPENDENT SEX DIFFERENCES IN STEROIDOGENIC FACTOR 1 KNOCKOUT MICE BRAIN.
- Authors
Büdefeld, Tomaž; Tobet, Stuart A.; Majdič, Gregor
- Abstract
Sex differences in brain morphology have been described in a number of species including humans. Gonadal hormones were shown to provide a major influence on brain sexual differentiation more than 50 years ago. A growing number of studies is providing evidence for roles of genetic factors, in particular sex chromosome complement, on brain sexual differentiation in mammals. In this review, hormone-independent brain sexual differentiation, with the emphasis on mice with a disruption of the SF-1 gene (SF-1 knockout, SF-1 KO) are discussed.
- Subjects
SEX differentiation (Embryology); SEX chromosomes; LABORATORY mice; HYPOTHALAMUS; NEUROPEPTIDE Y; BRAIN; MORPHOLOGY; GONADS; MAMMALS
- Publication
Slovenian Veterinary Research / Slovenski Veterinarski Zbornik, 2010, Vol 47, Issue 3, p167
- ISSN
1580-4003
- Publication type
Article