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- Title
Serum Leptin Levels in Patients with Ocular and Nonocular Behçet's Disease.
- Authors
Yalçındağ, F. Nilüfer; Kısa, Üçler; Batıoğlu, Figen; Yalçındağ, Ali; Özdemir, O¨zden; Çğlayan, Osman
- Abstract
Aims. To investigate serum leptin levels in Behçet's patients with or without ocular involvement compared with healthy subjects and the relationship between serum leptin and uveitis activity in patients with ocular involvement. Methods. Fifty-seven patients with Behçet's disease and 20 healthy control subjects were included in this study. While 27 patients had ocular involvement (18 had acute uveitis, 9 had inactive ocular involvement), 30 did not have ocular disease. C-reactive protein, alpha l-antitrypsin, and serum leptin levels were measured in all samples. Results. There was a significant difference between the patients with Behçet's disease and control group for both logarithm of leptin (P = .000) and logarithm of CRP (P = .031 ). Logarithm of leptin in nonocular Behçet's patients was significantly higher compared to its level in ocular Behçet's disease and controls (P = .009). There was a significant difference between the patients with active ocular disease and control group (P = .03). Conclusions. Leptin might have a possible role in the pathogenesis of Behçet's disease.
- Subjects
LEPTIN; SERUM; BEHCET'S disease; UVEITIS; C-reactive protein; ALPHA 1-antitrypsin
- Publication
Mediators of Inflammation, 2007, Vol 2007, Issue 1, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2007/31986