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- Title
The Ebf1 knockout mouse and glomerular maturation.
- Authors
Schmidt-Ott, Kai M
- Abstract
Mice deficient in the transcription factor early B-cell factor 1 (Ebf1) lack mature B lymphocytes but have additional phenotypes suggesting functions outside the hematopoietic system. Fretz et al. report that these mice also exhibit quantitative and qualitative developmental renal defects and develop progressive podocyte foot process effacement. The findings not only suggest that Ebf1 may be pivotal to the transcriptional podocyte network, but also illustrate the importance of distinguishing cell-autonomous and non-autonomous inputs to podocyte maturation and integrity.
- Subjects
TALL-1 (Protein); KIDNEY glomerulus; GLOMERULAR filtration rate; LYMPHOCYTES; KIDNEY disease risk factors; INTEGRITY; LEUCOCYTES
- Publication
Kidney International, 2014, Vol 85, Issue 5, p1014
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2013.472