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- Title
PPAR-[alpha] transcriptional activity is required to combat doxorubicin-induced podocyte injury in mice.
- Authors
Mori K; Mukoyama M; Nakao K
- Abstract
Immunosuppressants and inhibitors of the renin angiotensin system are major reagents to treat nephrotic syndrome but their clinical effects are not necessarily satisfactory. Injection of doxorubicin in several strains of mice causes nephrotic syndrome-like disorder. Zhou et al. report that PPAR-[alpha] expression is downregulated in murine doxorubicin nephropathy and a PPAR-[alpha] agonist, fenofibrate, partially ameliorates the disorder induced likely through stabilization of nephrin expression and suppression of apoptosis in podocytes, providing a new preventive strategy.
- Publication
Kidney International, 2011, Vol 79, Issue 12, p1274
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1038/ki.2011.36