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- Title
The sweet side of HIF.
- Authors
Haase, Volker H.
- Abstract
Hypoxia-inducible factors (HIFs) are oxygen-sensitive transcription factors that mediate cellular adaptation to hypoxia. Depending on the type of injury, activation of HIF signaling in renal cells may be renoprotective or promote fibrosis. Isoe and colleagues demonstrate that hyperglycemia activates HIF-1 in mesangial cells via carbohydrate response element binding protein (ChREBP), thus providing a novel link between alterations in systemic glucose homeostasis and HIF-regulated gene expression.
- Subjects
HYPOXEMIA; TRANSCRIPTION factors; HOMEOSTASIS; GENE expression; HYPERGLYCEMIA; SIGNALS &; signaling; FIBROSIS
- Publication
Kidney International, 2010, Vol 78, Issue 1, p10
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2010.112