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- Title
Targeting neurotransmitters: modulating pain response.
- Authors
Clauw D
- Abstract
The publication of the American College of Rheumatology criteria for fibromyalgia syndrome (FMS) is often considered the starting point of a major paradigm shift. By establishing a standardized case definition for FMS, the criteria enabled researchers to move forward and changed the way clinicians and researchers think of FMS, and more broadly, chronic pain. Whereas chronic pain was once thought to be acute pain that merely lasted too long, it is now recognized that the mechanisms underlying acute and chronic pain are markedly different from each other, and that acute and chronic pain respond to entirely different treatments. This article reviews the paradigm shift that needs to occur to take care of chronic pain more effectively, as we appreciate intra-individual differences in the neural processing of pain and recognize that various pharmacologic and nonpharmacologic modalities are better at treating central pain states such as FMS than treatments such as nonsteroidal anti-inflammatory drugs, opioids, and surgery that work well for acute and 'peripheral' pain. The article also presents a recommended approach to the treatment of FMS and its associated comorbidities.
- Publication
Johns Hopkins Advanced Studies in Medicine, 2009, Vol 9, Issue 4, p122
- ISSN
1530-3004
- Publication type
Journal Article