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- Title
Epstein- Barr virus in the enlarged salivary tissues of patients with Ig G4-related disease.
- Authors
Furukawa, Takatoshi; Shimotai, Yoshitaka; Ohta, Nobuo; Ishida, Akihiro; Kurakami, Kazuya; Suzuki, Hitoshi; Yamakawa, Mitsunori; Hongo, Seiji; Kakehata, Seiji
- Abstract
Objective Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high-serum IgG4 concentration and IgG4-producing plasma cell production with fibrotic or sclerotic changes in affected organs. We aimed to clarify the roles of Epstein-Barr virus (EBV) in patients with IgG4-RDs. Study Design and Setting A retrospective clinical study at the Yamagata University School of Medicine, Yamagata, Japan. Methods The patient group consisted of four males and four females with an average age of 62 years (range: 48-73). Expression of IgG4, latent member protein 1, EBV nuclear antigens-2, and EBV-encoded RNA in affected salivary glands from patients with IgG4-RD was examined by using immunohistochemistry and in situ hybridization. The copy number of EBV DNA in the salivary glands was also investigated by real-time polymerase chain reaction. Results All patients had hard masses in the salivary or lacrimal glands, or both, bilaterally. Serum concentrations of IgG4 were elevated in all cases (mean 589.1, range 129-1750), and IgG4-positive plasmacytes were observed in the involved salivary glands. Four patients developed potentially life-threatening systemic involvement after initial salivary gland swelling. EBV-associated molecules (EBNA and EBER) were overexpressed in the affected salivary glands. The copy number of EBV DNA was significantly higher in patients with potentially life-threatening systemic involvement than in patients without systemic involvement ( P < 0.05). Conclusion These results suggest that the copy number of EBV DNA could be useful as diagnostic findings in IgG4-RD to predict potentially life-threatening systemic involvement. Level of Evidence 4. Laryngoscope, 125:2079-2084, 2015
- Subjects
EPSTEIN-Barr virus; IMMUNOGLOBULIN G; SERUM; PLASMA cell diseases; SCLERA; SALIVARY glands
- Publication
Laryngoscope, 2015, Vol 125, Issue 9, p2079
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.25153