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- Title
Diagnostic radiation procedures and risk of prostate cancer.
- Authors
Myles, P.; Evans, S.; Lophatananon, A.; Dimitropoulou, P.; Easton, D.; Key, T.; Pocock, R.; Dearnaley, D.; Guy, M.; Edwards, S.; O'Brien, L.; Gehr-Swain, B.; Hall, A.; Wilkinson, R.; Eeles, R.; Muir, K.
- Abstract
Exposure to ionising radiation is an established risk factor for many cancers. We conducted a case-control study to investigate whether exposure to low dose ionisation radiation from diagnostic x-ray procedures could be established as a risk factor for prostate cancer. In all 431 young-onset prostate cancer cases and 409 controls frequency matched by age were included. Exposures to barium meal, barium enema, hip x-rays, leg x-rays and intravenous pyelogram (IVP) were considered. Exposures to barium enema (adjusted odds ratio (OR) 2.06, 95% confidence interval (CI) 1.01-4.20) and hip x-rays (adjusted OR 2.23, 95% CI 1.42-3.49) at least 5 years before diagnosis were significantly associated with increased prostate cancer. For those with a family history of cancer, exposures to hip x-rays dating 10 or 20 years before diagnosis were associated with a significantly increased risk of prostate cancer: adjusted OR 5.01, 95% CI 1.64-15.31 and adjusted OR 14.23, 95% CI 1.83-110.74, respectively. Our findings show that exposure of the prostate gland to diagnostic radiological procedures may be associated with increased cancer risk. This effect seems to be modified by a positive family history of cancer suggesting that genetic factors may play a role in this risk association.
- Subjects
PROSTATE cancer; RADIOTHERAPY; EPIDEMIOLOGY; ETIOLOGY of diseases; MEDICAL radiology; DIAGNOSTIC imaging; COMPARATIVE studies; DISEASE susceptibility; GENITOURINARY organ radiography; DOSE-response relationship (Radiation); RESEARCH methodology; MEDICAL cooperation; PROSTATE tumors; RADIATION carcinogenesis; RADIOGRAPHY; RESEARCH; EVALUATION research; CASE-control method
- Publication
British Journal of Cancer, 2008, Vol 98, Issue 11, p1852
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6604370