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- Title
Risk of developing Parkinson's disease among patients with asthma: a nationwide longitudinal study.
- Authors
Cheng, C. ‐ M.; Wu, Y. ‐ H.; Tsai, S. ‐ J.; Bai, Y. ‐ M.; Hsu, J. ‐ W.; Huang, K. ‐ L.; Su, T. ‐ P.; Li, C. ‐ T.; Tsai, C. ‐ F.; Yang, A. C.; Lin, W. ‐ C.; Pan, T. ‐ L.; Chang, W. ‐ H.; Chen, T. ‐ J.; Chen, M. ‐ H.
- Abstract
Background: A cross-sectional retrospective study suggested a link between allergic diseases and Parkinson's disease. However, the temporal association between asthma and Parkinson's disease remains unknown. Methods: From the Taiwan National Health Insurance Research Database, 10 455 patients who were diagnosed with asthma between 1998 and 2008 and aged ≥45 years and 41 820 age- and sex-matched controls were selected for our study and observed until the end of 2011. Those who developed Parkinson's disease during the follow-up period were identified. We also examined the asthma severity, as indicated by the frequency of admission (times per year) for asthma exacerbation, and the risk of subsequent Parkinson's disease. Results: Patients with asthma had an increased risk of developing Parkinson's disease (hazard ratio [HR]: 3.10, 95% confidence interval [CI]: 2.20-4.36) after we adjusted for demographic data, health system use, medical comorbidities, and medication use. Sensitivity tests yielded consistent findings after we excluded observations on the first year (HR: 2.90, 95% CI: 2.04-4.13) and first 3 years (HR: 2.46, 95% CI: 1.64-3.69). Patients with asthma who had more frequent admissions (times per year) during the follow-up period exhibited a greater risk of subsequent Parkinson's disease (>2: HR: 16.42, 95% CI: 5.88-45.91; 1-2: 12.69, 95% CI: 5.03-31.71; 0-1: HR: 2.92, 95% CI: 1.91-4.49). Conclusion: Patients with asthma had an elevated risk of developing Parkinson's disease later in life, and we observed a dose-dependent relationship between greater asthma severity and a higher risk of subsequent Parkinson's disease.
- Subjects
DISEASE risk factors; PARKINSON'S disease; ASTHMATICS; LONGITUDINAL method; ALLERGIES; DISEASE exacerbation
- Publication
Allergy, 2015, Vol 70, Issue 12, p1605
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.12758