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- Title
Septic Hyperinflammation—Is There a Role for Extracorporeal Blood Purification Techniques?
- Authors
Jarczak, Dominik; Kluge, Stefan; Nierhaus, Axel
- Abstract
This manuscript investigates the role of extracorporeal blood purification techniques in managing septic hyperinflammation, a critical aspect of sepsis characterized by an uncontrolled immune response leading to multiorgan dysfunction. We provide an overview of sepsis, focusing on the dynamics of immune response, the involvement of neutrophils, and the role of the endothelium in the disease's progression. It evaluates the effectiveness of various blood purification methods, including high-cut-off membranes, high-volume hemofiltration, adsorption techniques, and albumin dialysis, in removing cytokines and endotoxin and improving hemodynamic stability. Despite some very promising results, we conclude that the current evidence does not strongly support these techniques in significantly improving survival rates in septic patients, clearly underlining the need for further research.
- Subjects
INFLAMMATION; ENDOTHELIUM diseases; IMMUNE response; ENDOTOXINS; SEPSIS; NEUTROPHILS
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 6, p3120
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25063120