We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Functional status at 18 months of age as a predictor of childhood disability after neonatal hypoxic-ischemic encephalopathy.
- Authors
Natarajan, Girija; Shankaran, Seetha; Pappas, Athina; Bann, Carla; Tyson, Jon E; McDonald, Scott; Das, Abhik; Hintz, Susan; Vohr, Betty; Higgins, Rosemary
- Abstract
Aim In children with neonatal hypoxic-ischemic encephalopathy (HIE), we examined the association between 18-month functional status by parental report and disability at 6-7 years. Method Prospective observational study involving participants in the NICHD randomized controlled trial of hypothermia for HIE. Parent questionnaires-Functional Status-II (FS-II), Impact on Family (IOF) and Family Resource Scale (FRS) at 18 months were correlated with 6- to 7-year developmental assessments. Disability at 6-7 years was defined as IQ < 70, gross motor functional classification scale level III-V, bilateral blindness, deafness, or epilepsy. Results Rates of severe HIE (32 vs. 15%), public insurance (73% vs. 47%) and IOF scales were higher and mean (SD) FS-II independence (I) {54 (SD 35) vs. 98 (SD 8)} and general health (GH) {87 (SD 14) vs. 98 (SD 6)} scores were significantly lower in children with disability (n=37) at 6-7 years, compared to those (n=74) without disability. FS-II I scores were significantly associated with disability (OR 0.92; 95% CI 0.87-0.97; p=0.003). On path analysis, severe HIE, greater IOF and public insurance were associated with poorer 18-month FS-II I scores, which, in turn, were associated with disability at 6 to 7 years. Interpretation Poor independent functioning by parental report at 18 months in children with HIE was associated with childhood disability.
- Subjects
BINSWANGER'S disease; CHILDREN with disabilities; AGE factors in disease; PEDIATRIC neurology; HYPOTHERMIA; DEVELOPMENTAL neurobiology
- Publication
Developmental Medicine & Child Neurology, 2014, Vol 56, Issue 11, p1052
- ISSN
0012-1622
- Publication type
Article
- DOI
10.1111/dmcn.12512