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- Title
Metabolomics Analysis of the Lipid-Regulating Effect of Allium hookeri in a Hamster Model of High-Fat Diet-Induced Hyperlipidemia by UPLC/ESI-Q-TOF Mass Spectrometry.
- Authors
Jang, Gwang-Ju; Sung, Mi Jeong; Hur, Haeng Jeon; Yoo, Miyoung; Choi, Jung Hoon; Hwang, In Koo; Lee, Sanghee
- Abstract
Hyperlipidemia is a risk factor for atherosclerotic cardiovascular disease and is a major public health concern. Allium hookeri (AH) is an Allium species containing high levels of bioactive organosulfur compounds such as methiin and cycloalliin. AH exerts hypolipidemic effects in animals fed a high-fat diet. However, there exists little information on the mechanisms underlying these effects. To address this issue, we used a metabolomic approach based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry to identify factors mediating the lipid-lowering effects of AH. Principal component and partial least-squares discriminant analyses of serum metabolome profiles revealed 25 metabolites as potential biomarkers for the effects of AH on lipid levels. These compounds were predominantly phospholipids, including phosphatidylcholines (PCs), lysoPCs, and lysophosphatidylethanolamines. Glycerophospholipid metabolism was identified as a significantly enriched pathway. These results provide mechanistic insight into the antihyperlipidemic effects of AH and evidence for its efficacy as a therapeutic agent.
- Subjects
DRUG therapy for hyperlipidemia; LECITHIN metabolism; ANIMAL experimentation; BIOMARKERS; DISCRIMINANT analysis; FACTOR analysis; FAT content of food; HAMSTERS; HIGH performance liquid chromatography; HYPERLIPIDEMIA; LIPIDS; MASS spectrometry; PHOSPHOLIPIDS; PLANT extracts; METABOLOMICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2018, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2018/5659174