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- Title
A genome-wide identification and analysis of the basic helix-loop-helix transcription factors in the ponerine ant, Harpegnathos saltator.
- Authors
Ake Liu; Yong Wang; Chunwang Dang; Debao Zhang; Huifang Song; Qin Yao; Keping Chen
- Abstract
Background: The basic helix-loop-helix (bHLH) transcription factors and their homologs form a superfamily that plays essential roles in transcriptional networks of multiple developmental processes. bHLH family members have been identified in over 20 organisms, including fruit fly, zebrafish, human and mouse. Result: In this study, we conducted a genome-wide survey for bHLH sequences, and identified 57 bHLH sequences encoded in complete genome sequence of the ponerine ant, Harpegnathos saltator. Phylogenetic analysis of the bHLH domain sequences classified these genes into 38 bHLH families with 23, 14, 10, 1, 8 and 1 members in group A, B, C, D, E and F, respectively. The number of PabHLHs (ponerine ant bHLHs) with introns is higher than many other insect species, and they are found to have introns with average lengths only inferior to those of pea aphid. In addition, two H. saltator bHLHs named PaCrp1 and PaSide locate on two separate contigs in the genome. Conclusions: A putative full set of PabHLH genes is comparable with other insect species and genes encoding Oligo, MyoRb and Fig? were not found in genomes of all insect species of which bHLH family members have been identified. Moreover, in-family phylogenetic analyses indicate that the PabHLH genes are more closely related with Apis mellifera than others. The present study will serve as a solid foundation for further investigations into the structure and function of bHLH proteins in the regulation of H. saltator development.
- Subjects
ANTS; TRANSCRIPTION factors; FRUIT flies; GENOMES; INTRONS
- Publication
BMC Evolutionary Biology, 2012, Vol 12, Issue 1, p165
- ISSN
1471-2148
- Publication type
Article
- DOI
10.1186/1471-2148-12-165